I. M. Ong

Assessing Immune Factors in Maternal Milk and Paired Infant Plasma Antibody Binding to Human Rhinoviruses

The paper identifies maternal milk and infant plasma antibody binding to human rhinovirus epitopes using high-density peptide arrays, revealing isotype-specific and virus-specific binding patterns.

Individual dietary amino acid restrictions induce distinct metabolic and chromatin states

The paper investigates how dietary restriction of specific essential amino acids affects metabolism and chromatin states in mice, finding distinct effects for methionine, leucine, and isoleucine.

Antibody landscape of C57BL/6 mice cured of B78 melanoma via immunotherapy

The paper identifies antibodies targeting melanoma peptides in C57BL/6 mice cured of B78 melanoma via immunotherapy, using proteome arrays and ELISA validation.

Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice

This study shows that reducing dietary isoleucine improves metabolic health, reduces frailty, and extends lifespan in genetically diverse mice.

Integrating Subclonal Response Heterogeneity to Define Cancer Organoid Therapeutic Sensitivity

The paper evaluates individual patient-derived cancer organoids using optical metabolic imaging to predict therapeutic response and identify subclonal populations and resistance mechanisms.

The landscape of antibody binding in SARS-CoV-2 infection

This study identifies B cell epitopes across the SARS-CoV-2 proteome using peptide microarrays, showing antibody reactivity to multiple viral proteins and correlations with illness severity.

Development and Characterization of Patient-Derived Xenografts from Non-Small Cell Lung Cancer Brain Metastases

This study establishes and characterizes patient-derived xenografts of NSCLC brain metastases, showing strong phenotypic and molecular correlation with original tumors and therapeutic response to targeted treatments.

Transcriptional elongation machinery controls vulnerability of breast cancer cells to PRC2 inhibitors

This study shows that CTR9 loss in breast cancer cells increases H3K27me3 levels and switches PRC2 subtype, making cells more sensitive to PRC2 inhibitors.