RNA fragment assembly with experimental restraints
Grzegorz ChojnowskiiD, Rafał ZaborowskiiD, Marcin MagnusiD, Sunandan MukherjeeiD, Janusz Marek BujnickiiD
Abstract
We present RNA Masonry, a computer program and a web service for a fully automated assembly of RNA fragments into geometrically plausible models fulfilling user-provided secondary structure constraints and restraints on tertiary contacts and Small Angle X-ray Scattering (SAXS) data. We illustrate the method description with its recent application to structural studies of viral RNAs with SAXS restraints. The program web server is available at http://iimcb.genesilico.pl/rnamasonry. Contactgchojnowski@embl-hamburg.de
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