Sarah C. Keane

This study investigates the temperature-dependent unfolding mechanism of the Listeria prfA RNA thermometer, revealing how structural changes at the ribosome binding site and upper helix regulate translation.

This study determines the structure of pre-miR-20a and identifies structural features that regulate its Dicer-TRBP processing and maturation efficiency.

The paper identifies eight small molecules that bind to NPSL2, a regulatory element in oncomiR-1, using virtual screening and experimental validation.

The paper identifies novel ligands that bind to the Dicer cleavage site of pre-miR-31 through in silico screening and experimental validation.

The paper validates SreA as a functional SAM-I riboswitch in Listeria monocytogenes through ligand binding, structure, and transcription assays, showing it binds SAM at lower concentrations than other SAM riboswitches but does not terminate transcription.

This paper uses SAXS and SANS to analyze conformational changes in RNA:RNA complexes, validating and improving AlphaFold 3 predictions through isotope labeling and contrast matching.

This study demonstrates that steric blocking antisense oligonucleotides can inhibit pre-miRNA processing by targeting structural junctions, validating their use in modulating miRNA production.