The local anaesthetic procaine prodrugs ProcCluster(R) and Procaine-hydrochloride impair SARS-CoV-2 replication in vitro
C. Häring, J. Schroeder, B. Loeffler, B. Engert, C. Ehrhardt
Abstract
The SARS-CoV-2 pandemic has had the world in suspense for more than a year. Even if more and more vaccines are approved there is still an urgent need for efficient antiviral treatment strategies. Here, we present data on the inhibitory effect of the local anaesthetic procaine, especially the prodrugs ProcCluster(R) and Procaine-hydrochloride on SARS-CoV-2 infection in vitro. Remarkably, similar effects could be shown on the replication of influenza A viruses in cell culture systems. Since the active ingredient procaine is well-tolerated and already used in the clinics for anaesthetic purposes, the further investigation of this substance could enable its reuse in antiviral therapy, including SARS-CoV-2.
02 /Specification & Classification
Click any tag to browse matching papers- Research Focus
- Approach
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- The repurposed drugs suramin and quinacrine inhibit cooperatively in vitro SARS-CoV-2 3CLpro
R. J. Eberle, D. S. Olivier, … M. A. Coronado·bioRxiv·Nov 11, 2020
- Inhibition of the replication of SARS-CoV-2 in human cells by the FDA-approved drug chlorpromazine
M. Plaze, D. Attali, … R. Gaillard·bioRxiv·May 5, 2020
- Development of highly potent non-covalent inhibitors of SARS-CoV-2 3CLpro
- In Vitro Inhibition of SARS-CoV-2 Infection by Bromhexine hydrochloride
R. Martins, I. Ferreira, … E. Arruda·bioRxiv·Dec 23, 2022
- Anthracyclines inhibit SARS-CoV-2 infection
- Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro