R. Martins

In Vitro Inhibition of SARS-CoV-2 Infection by Bromhexine hydrochloride

This study shows bromhexine hydrochloride inhibits SARS-CoV-2 infection in vitro by targeting TMPRSS2, reducing viral entry and progeny without direct virucidal activity.

Ultrasound inhibits SARS-CoV-2 infectivity in vitro

This study shows ultrasound can reduce SARS-CoV-2 infectivity in vitro without causing heat or cavitation.

Targeting C5aR1 signaling reduced neutrophil extracellular traps and ameliorates COVID-19 pathology

This study shows that inhibiting C5aR1 signaling reduces neutrophil extracellular traps and improves lung pathology in COVID-19.

A Protective Inter-Organ Communication Response Against Life-Threatening Malarial Anemia

The paper shows that kidney cells reprogram iron metabolism to prevent severe malarial anemia by supporting erythropoiesis.

A HYPOMETABOLIC DEFENSE STRATEGY AGAINST PLASMODIUM INFECTION

The paper shows that Plasmodium infection induces hypoglycemia in mice through heme-driven suppression of hepatic glucose production, which limits parasite growth but promotes gametocyte production.

Natural infection with Giardia is associated with altered community structure of the human and canine gut microbiome.

This study investigates the impact of Giardia infection on gut microbiome structure in dogs and children, finding significant microbiome remodeling associated with infection.

Heme induces innate immunity memory

This study shows heme induces trained immunity in human and murine cells, leading to long-term protection against bacterial sepsis through epigenetic and transcriptional changes.

CXCL5-mediated recruitment of neutrophils into the peritoneal cavity of Gdf15-deficient mice protects against abdominal sepsis

This study shows that GDF15 deficiency in mice protects against abdominal sepsis by enhancing CXCL5-mediated neutrophil recruitment to the peritoneum, improving bacterial control.