bioRxivSynthetic BiologyPreprint
Re-introduction of endogenous pathways for propionyl-CoA, 1-propanol and propionate formation in Escherichia coli
Abstract
In a previous study, we found that 2-ketobutyrate (2-KB) was seriously degraded in Escherichia coli. In the present investigation, we tried to clarify the products of that degradation process, and intriguingly reconfirmed that 2-KB is chopped up to form propionyl-CoA, 1-propanol and propionate. This short commentary re-introduces efficient endogenous pathways for production of value-added odd-chain compounds such as propionyl-CoA-derived chemicals.
- Citations
- 2
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Constructing an ethanol utilization pathway in Escherichia coli to produce acetyl-CoA derived compounds
- Propionate oxidation by Geobacter sulfurreducens is electron acceptor dependent
David Hernández-Villamor, Jean-Romain Bautista Angeli, … Antonin Prévoteau·Applied and Environmental MicrobiologyPeer-reviewed·May 21, 2026
- An alternative malonyl-CoA producing pathway in nature
- A kinetic model of the central carbon metabolism for acrylic acid production in Escherichia coli
A. Oliveira, J. Rodrigues, … O. Dias·bioRxiv·May 13, 2020
- Cell-free prototyping enables implementation of optimized reverse beta-oxidation pathways in heterotrophic and autotrophic bacteria
Bastian Vögeli, Luca Schulz, … Michael C. Jewett·Nature CommunicationsPeer-reviewed·Jun 1, 2022
- Biological upgrading of C1-C2 products of electrocatalytic CO 2 reduction to C4-C6 carboxylates
Chao Xu, Jonathan K. Otten, … Eleftherios Terry Papoutsakis·bioRxiv·Aug 4, 2026