Bastian Vögeli

This study presents a cell-free biocatalytic system for converting one-carbon substrates into acetyl-CoA using a synthetic pathway called ReForm.

The paper optimizes and implements reverse beta-oxidation pathways in bacteria for carbon-negative synthesis of C4-C6 acids and alcohols, achieving high product titers in engineered strains.

The paper designs and characterizes trivalent miniprotein binders that neutralize SARS-CoV-2 variants with low pM IC50 values and provide prophylactic and therapeutic protection in mice.

This paper develops an automated cell-free platform for rapid antibody discovery and screening, demonstrating its effectiveness with SARS-CoV-2 neutralizing antibodies.

This study identifies a new carbon fixation pathway in E. coli using only native enzymes and demonstrates its in vivo feasibility through genetic engineering.

This paper develops modular plasmids for cell-free expression and genetic assembly in Clostridium to accelerate biosynthetic pathway testing.