Journal of Alzheimer s DiseasePhysiologyPeer-reviewed journal article
Lifespan of male and female APP/PS1 and APPNL-F/NL-F mouse models of Alzheimer's disease
Hannah Roberts, Yimin FangiD, Kathleen Quinn, Tiarra HilliD, Mackenzie R. PeckiD, Andrzej BartkeiD, Kevin N. HascupiD, Erin R. HascupiD
Abstract
Alzheimers disease (AD) disproportionately affects women, yet most preclinical research studies are male-centric. We performed lifespan analyses of male and female AD mouse models (APP/PS1 and APPNL-F/NL-F) and their shared genetic background control (C57BL/6). Survival curves support significant sex differences between within genotypes. Minimal longevity revealed increased age in male APP/PS1, and decreased age in APPNL-F/NL-F mice. Maximal longevity revealed an increased average age in males. Furthermore, median lifespan differed between sex and genotype. This study supports sexual dimorphic survival in two mouse models of AD, emphasizing the need to examine mechanisms and treatments in both sexes.
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