Author

Ryan K. Tisdale

SRI InternationalORCID 0000-0002-8239-6576Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:mouse· 5 Assay:electronic health records· 4 Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Thomas S. KilduffiD· 5 shared Yu SuniD· 5 shared Sunmee ParkiD· 4 shared Jasmine HeuiD· 3 shared Meghan HaireiD· 3 shared Shun‐Chieh MaiD· 3 shared Giancarlo AlloccaiD· 2 shared Stephen R. MorairtyiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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5 shared papersNeuroscience

Thomas S. KilduffORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Early origin of sugar sensing in jawed vertebrates

Qiaoyi Liang, Yasuka Toda, Pauline Affatato, Gentoku Kakizaki, Hitomi Kaname, Kayoko Suzuki, Tae Kuramoto, Meng‐Ching Ko, Maxime Policarpo, Julia F. Cramer, Akihiro Itoigawa, Keisuke Furumitsu, Keren R. Sadanandan, Shigehiro Kuraku, Atsuko Yamaguchi, , Maude W. Baldwin

This study investigates the evolutionary origin of sugar sensing in vertebrates, finding that it predates angiosperms and involves multiple independent T1R-based mechanisms.

bioRxiv · Aug 28, 2026 · PreprintEvolutionary Biology

Long Wake/Short Sleep Bouts and Hyperactivity with Advanced Age in a Mouse Model of Early Onset Alzheimers Disease

Ryan K. Tisdale, Yu Sun, Stephanie R. Miller, Stephanie M. Lee, Sunmee Park, Jia Shin, Giancarlo Allocca, Jorge J. Palop, Thomas S. Kilduff

This paper investigates sleep and activity patterns in a mouse model of early onset Alzheimer's disease, finding a long wake/short sleep phenotype more pronounced in females.

bioRxiv · Mar 30, 2026 · PreprintNeuroscience

TAAR2-9 Knockout Mice Exhibit Reduced Wakefulness and Disrupted REM Sleep

Sunmee Park, Jasmine Heu, Gavin Scheldrup, Ryan K. Tisdale, Yu Sun, Meghan Haire, Shun‐Chieh Ma, Marius Christian Hoener, Thomas S. Kilduff

This study examines the effects of TAAR2-9 knockout on sleep/wake patterns in mice, finding altered REM sleep and wakefulness but no difference in homeostatic response to sleep loss.

bioRxiv · Sep 9, 2024 · PreprintNeuroscience

Peripheral vs. Core Body Temperature as Hypocretin/Orexin Neurons Degenerate: Exercise Mitigates Increased Heat Loss

Yu Sun, Ryan K. Tisdale, Akira Yamashita, Thomas S. Kilduff

This study shows that Hcrt/Ox neuron degeneration increases heat loss by reducing sympathetic vasoconstrictor tone, and that exercise mitigates this effect in mice.

Peptides · Jun 1, 2023Peer-reviewedNeuroscience

Evaluation of the Efficacy of the Hypocretin/orexin Receptor Agonists TAK-925 and ARN-776 in Narcoleptic Orexin/tTA; TetO-DTA Mice

Yu Sun, Alok Ranjan, Ryan K. Tisdale, Shun‐Chieh Ma, Sunmee Park, Meghan Haire, Jasmine Heu, Stephen R. Morairty, Xiaoyu Wang, Daniel M. Rosenbaum, Noelle Sevilir Williams, Jef K. De Brabander, Thomas S. Kilduff

This study evaluates the efficacy of TAK-925 and ARN-776, HCRTR2 agonists, in reducing cataplexy and promoting wakefulness in narcoleptic mice.

bioRxiv · Dec 9, 2022 · PreprintNeuroscience

The Development of Sleep/Wake Disruption and Cataplexy as Hypocretin/Orexin Neurons Degenerate in Male vs. Female Orexin/tTA; TetO-DTA Mice

Yu Sun, Ryan K. Tisdale, Sunmee Park, Shun‐Chieh Ma, Jasmine Heu, Meghan Haire, Giancarlo Allocca, Akihiro Yamanaka, Stephen R. Morairty, Thomas S. Kilduff

This study compares the development of narcoleptic symptoms in male and female orexin-tTA; TetO-DTA mice, finding females develop symptoms faster but both sexes show similar symptoms by week 6.

SLEEP · Feb 19, 2022Peer-reviewedNeuroscience