Thomas S. Kilduff

This study identifies Sst-Chodl inhibitory neurons that promote cortical synchrony and sleep by exerting long-range inhibition during low-arousal states.

This paper investigates sleep and activity patterns in a mouse model of early onset Alzheimer's disease, finding a long wake/short sleep phenotype more pronounced in females.

This study examines the effects of TAAR2-9 knockout on sleep/wake patterns in mice, finding altered REM sleep and wakefulness but no difference in homeostatic response to sleep loss.

This study shows that TAAR1 partial agonism increases wakefulness and reduces NREM sleep in mice, with D1R and D2R antagonists modulating these effects differently.

This study shows that Hcrt/Ox neuron degeneration increases heat loss by reducing sympathetic vasoconstrictor tone, and that exercise mitigates this effect in mice.

This study evaluates the efficacy of TAK-925 and ARN-776, HCRTR2 agonists, in reducing cataplexy and promoting wakefulness in narcoleptic mice.

This study compares the development of narcoleptic symptoms in male and female orexin-tTA; TetO-DTA mice, finding females develop symptoms faster but both sexes show similar symptoms by week 6.

This study shows that ablating both orexin and MCH neurons in mice leads to increased wakefulness, reduced sleep, and more severe cataplexy compared to ablating orexin neurons alone.