Public Health Response to Pan-Resistant Pseudomonas aeruginosa Sequence Type 309 with Tandem Guiana Extended Spectrum Beta Lactamases Genetic Characterization and In Vivo Efficacy Assessment using Translational Murine Model.

Through phenotypic and genetic profiling, we identified the first pan resistant Pseudomonas aeruginosa high-risk sequence type 309 (ST-309) with Guiana Extended Spectrum {beta}-Lactamase (GES) in California, prior to a national outbreak of VIM-GES Pseudomonas aeruginosa (1). Our findings highlight detection and use of the translational murine model provide treatment implications for this emerging Pseudomonas aeruginosa.