T. T. Tran

Cefiderocol heteroresistance associated with mutations in TonB-dependent receptor genes in Pseudomonas aeruginosa of clinical origin

This study examines TBDR mutations in P. aeruginosa clinical isolates and their association with cefiderocol resistance and heteroresistance.

LiaX is a surrogate marker for cell-envelope stress and daptomycin non-susceptibility in Enterococcus faecium

This study identifies LiaX as a surrogate marker for cell-envelope stress and daptomycin non-susceptibility in Enterococcus faecium and validates its use through ELISA and genomic analysis of clinical isolates.

Titers of antibodies the receptor-binding domain (RBD) of ancestral SARS-CoV-2 are predictive for levels of neutralizing antibodies to multiple variants

This study shows that anti-RBDwt titers correlate with neutralizing antibody levels against multiple SARS-CoV-2 variants and proposes a method to improve immunomonitoring precision and throughput.

Evolution of Enterococcus faecium to A Combination of Daptomycin and Fosfomycin Reveals Distinct and Diverse Adaptive Strategies

This study investigates how Enterococcus faecium develops resistance to a combination of daptomycin and fosfomycin, finding that resistance mechanisms are largely independent and that fosfomycin resistance involves changes in phosphoenolpyruvate flux.

Beyond Spike: Identification of nine highly prevalent SARS-CoV-2-specific CD8 T-cell epitopes in a large Norwegian cohort

The paper identifies nine prevalent SARS-CoV-2-specific CD8 T-cell epitopes in a Norwegian cohort, showing strong correlation between immunoprevalence and immunodominance.

Daptomycin resistance in Enterococcus faecium can be delayed by disruption of the LiaFSR stress response pathway

This study shows that disrupting the LiaFSR pathway in Enterococcus faecium delays daptomycin resistance development, suggesting potential for combinatorial therapy with a LiaFSR inhibitor.

Genomic epidemiology of vancomycin resistant Enterococcus faecium (VREfm) in Latin America: Revisiting the global VRE population structure

This study characterizes the genomic structure of VREfm in Latin America and reconstructs the global population structure, revealing two main clinical clades and recombination-driven evolution.

Environment Shapes the Accessible Daptomycin Resistance Mechanisms in Enterococcus faecium

This study shows how different environments shape daptomycin resistance mechanisms in Enterococcus faecium through distinct evolutionary pathways.

Extremely Drug-Resistant Pseudomonas aeruginosa ST309 Harboring Tandem GES Enzymes: A Newly Emerging Threat in the United States

The paper identifies two U.S. clinical isolates of Pseudomonas aeruginosa ST309 resistant to carbapenems and beta-lactam/beta-lactamase inhibitor combinations, harboring tandem GES 19 and 26 enzymes, and reports successful treatment with ceftazidime/avibactam plus aztreonam.

Functional analysis of African Xanthomonas oryzae pv. oryzae TALomes reveals a new susceptibility gene in bacterial leaf blight of rice

The paper identifies a new susceptibility gene in rice by analyzing TAL effector repertoires and their functional roles in bacterial leaf blight.

Efficient enrichment cloning of TAL effector genes from Xanthomonas

The paper develops an efficient method to clone TAL effector genes from Xanthomonas by optimizing restriction digestions and size fractionation.