W. R. Miller

Cefiderocol heteroresistance associated with mutations in TonB-dependent receptor genes in Pseudomonas aeruginosa of clinical origin

This study examines TBDR mutations in P. aeruginosa clinical isolates and their association with cefiderocol resistance and heteroresistance.

Membrane Lipids Augment Cell Envelope Stress Signaling and Resistance to Antibiotics and Antimicrobial Peptides in Enterococcus faecalis

This study identifies the MadRS system and its operon madEFG as mediators of resistance to antimicrobial peptides and antibiotics in Enterococcus faecalis, linking membrane lipid changes to stress response and virulence.

LiaX is a surrogate marker for cell-envelope stress and daptomycin non-susceptibility in Enterococcus faecium

This study identifies LiaX as a surrogate marker for cell-envelope stress and daptomycin non-susceptibility in Enterococcus faecium and validates its use through ELISA and genomic analysis of clinical isolates.

Molecular Basis of Cell Membrane Adaptation in Daptomycin-Resistant Enterococcus faecalis

This study identifies the role of cardiolipin synthase and the LiaFSR system in daptomycin resistance by redistributing anionic phospholipids in Enterococcus faecalis.

Evolution of Enterococcus faecium to A Combination of Daptomycin and Fosfomycin Reveals Distinct and Diverse Adaptive Strategies

This study investigates how Enterococcus faecium develops resistance to a combination of daptomycin and fosfomycin, finding that resistance mechanisms are largely independent and that fosfomycin resistance involves changes in phosphoenolpyruvate flux.

Daptomycin resistance in Enterococcus faecium can be delayed by disruption of the LiaFSR stress response pathway

This study shows that disrupting the LiaFSR pathway in Enterococcus faecium delays daptomycin resistance development, suggesting potential for combinatorial therapy with a LiaFSR inhibitor.

Environment Shapes the Accessible Daptomycin Resistance Mechanisms in Enterococcus faecium

This study shows how different environments shape daptomycin resistance mechanisms in Enterococcus faecium through distinct evolutionary pathways.

Extremely Drug-Resistant Pseudomonas aeruginosa ST309 Harboring Tandem GES Enzymes: A Newly Emerging Threat in the United States

The paper identifies two U.S. clinical isolates of Pseudomonas aeruginosa ST309 resistant to carbapenems and beta-lactam/beta-lactamase inhibitor combinations, harboring tandem GES 19 and 26 enzymes, and reports successful treatment with ceftazidime/avibactam plus aztreonam.