Extremely Drug-Resistant Pseudomonas aeruginosa ST309 Harboring Tandem GES Enzymes: A Newly Emerging Threat in the United States
A. Khan, T. T. Tran, R. Rios, B. Hanson, W. C. Shropshire, Z. Sun, L. Diaz, A. Q. Dinh, A. Wanger, L. Ostrosky-Zeichner, T. Palzkill, C. A. Arias, W. R. Miller
Abstract
Two ST309 Pseudomonas aeruginosa clinical isolates resistant to carbapenems and newer {beta}-lactam/{beta}-lactamase inhibitor combinations were found to harbor the extended spectrum beta-lactamases GES 19 and 26 genetically clustered in tandem. The combination of ceftazidime/avibactam plus aztreonam achieved cure in one patient. Phylogenetic analysis suggests that ST309 P. aeruginosa carrying tandem GES are an emerging lineage in the United States.
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