Andrew Chatr‐aryamontri

Isw2-mediated chromatin remodeling governs antifungal tolerance and heteroresistance in Candida albicans

This study identifies Isw2-mediated chromatin remodeling as a regulator of antifungal tolerance and heteroresistance in Candida albicans, revealing its role in suppressing CRZ1 transcription and modulating drug responses.

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture

The paper presents a chemical-genetic interaction matrix derived from CRISPR/Cas9 screens, revealing drug mechanisms and genetic architecture in human cells.

A platform for the systematic interrogation of genetic interactions in human cells: 26 gene by genome-wide double knockout screens as a proof of concept

The paper introduces a method for systematically studying genetic interactions in human cells using CRISPR/Cas9 screens and demonstrates its effectiveness through 26 gene by genome-wide knockout screens.

On-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions

This study shows CDK11 is critical for cancer cell survival and identifies 1p36 deletions as a biomarker for CDK11 inhibitor sensitivity, but on-target toxicity limits therapeutic efficacy.

Contextual diversity of the human cell-essential proteome

The paper identifies 2,280 essential genes in human B-cell lymphoma cells using an EKO library and RANKS tool, revealing context-specific essentiality and evolutionary patterns.