bioRxivDevelopmental BiologyPreprint
The lottery of spermatogenesis
Abstract
The causes of male infertility are yet to be fully understood. Here, we propose that male infertility can be partly attributed to the insufficiency of cytoplasmically-inherited proteins in sperms. Using a simple stochastic model of spermatogenesis, we show that in a range of parameters, the proportion of viable sperms can be reduced simply due to stochastic transmission of proteins from spermatogonia to spermatids.
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