A. Imhof

The role of RNA in the maintenance of chromatin domains as revealed by antibody mediated proximity labelling coupled to mass spectrometry

The paper introduces AMPL-MS to study chromatin domains in Drosophila, showing RNA's role in maintaining their proteomic composition.

Decrypting the functional design of unmodified translation elongation factor P

This study identifies unmodified EF-P variants from Rhodomicrobium vannielii that restore function in E. coli lacking EF-P modifications, revealing design principles for polyproline synthesis.

Identification of two β-cell subtypes by 7 independent criteria

The paper identifies two distinct β-cell subtypes, βHI and βLO, using seven independent criteria and shows that H3K27me3 dosage regulates their ratio in vivo.

A chemotactic sensor controls Salmonella-host cell interaction

The paper shows that the chemotactic sensor CheM controls Salmonella's ability to invade host cells by regulating the surface retention of the adhesin SiiE.

The Integrity of the Speciation Core Complex is necessary for centromeric binding and reproductive isolation in Drosophila

This study identifies a six-subunit Speciation Core Complex containing Hmr and Lhr, showing Hmr's role in centromeric binding and hybrid male lethality in Drosophila.

Imperfect innate immune antagonism renders SARS-CoV-2 vulnerable towards IFN-γ and -{lambda}

This study identifies SARS-CoV-2's vulnerability to IFN-γ and -λ due to its inefficient antagonism of type I and II IFN responses, suggesting potential therapeutic strategies.

Dietary intervention improves health metrics and life expectancy of the genetically obese DU6 (Titan) mouse

The study characterizes the Titan mouse as a model for metabolically unhealthy obesity and shows that dietary intervention improves its health and extends lifespan.

Helicobacter hepaticus as disease driver in a novel CD40-mediated model of colitis

This study identifies Helicobacter hepaticus as a disease driver in a CD40-mediated colitis model by showing its role in inducing inflammatory immune responses through specific antigen recognition.

Imaging mass spectrometry and shotgun proteomics reveal dysregulated pathways in male infertility

The paper uses proteomics and imaging mass spectrometry to identify dysregulated pathways in a mouse model of male infertility.

Chromosome organization by a conserved condensin-ParB system in the actinobacterium Corynebacterium glutamicum

This study investigates the role of ParB and condensin complexes in chromosome organization in Corynebacterium glutamicum, revealing distinct functions for different condensin paralogs.

Spt6 is a maintenance factor for centromeric CENP-A

This study shows Spt6 maintains centromeric CENP-A by preventing its loss during transcription, in both Drosophila and human cells.

Intricate structure of the interphase chromocenter revealed by the analysis of a factor involved in species formation

The paper uses microscopy and biotinylation to map HMR and HP1a bound chromatin, revealing an intricate structure of the chromocenter and a role for HMR in separating heterochromatin from centromeric chromatin.