Chronically implantable LED arrays for behavioral optogenetics in primates.

Rishi Rajalingham; Michael Sorenson; Reza Azadi; Simon Bohn; James J. DiCarlo; Arash Afraz

doi:10.1038/s41592-021-01238-9

NeuroscienceNature MethodsAug 30, 2021

Peer-reviewed journal article

Chronically implantable LED arrays for behavioral optogenetics in primates.

Rishi Rajalingham iD, Michael Sorenson, Reza Azadi iD, Simon Bohn iD, James J. DiCarlo iD, Arash Afraz iD

Abstract

Challenges in behavioral optogenetics in large brains demand development of a chronically implantable platform for light delivery. We have developed Opto-Array, a chronically implantable array of LEDs for high-throughput optogenetic perturbation in non-human primates. We tested the Opto-Array in the primary visual cortex of a macaque monkey, and demonstrated that optogenetic cortical silencing by the Opto-Array results in reliable retinotopic visual deficits on a luminance discrimination task.

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