bioRxivPhysiologyPreprint
Human Heart Failure Alters Mitochondria and Fiber 3D Structure Triggering Metabolic Shifts
Z. Vue, P. T. Ajayi, K. Neikirk, A. Murphy, P. Prasad, B. C. Jenkins, L. Vang, E. Garza-Lopez, M. Mungai, A. G. Marshall, H. K. Beasley, M. Killion, R. Parker, J. Anukodem, K. Lavine, O. Ajijola, B. Mobley, D.-F. Dai, V. Exil, A. Kirabo, Y. Ru Su, K. Tomasek, X. Zhang, C. N. Wanjalla, D. L. Hubert, , A. Hinton
Abstract
This study, utilizing SBF-SEM, reveals structural alterations in mitochondria and myofibrils in human heart failure (HF). Mitochondria in HF show changes in structure, while myofibrils exhibit increased cross-sectional area and branching. Metabolomic and lipidomic analyses indicate concomitant dysregulation in key pathways. The findings underscore the need for personalized treatments considering individualized structural changes in HF.
- organism: human
- assay: imaging
- research focus: cell type annotation
- research focus: metabolism & bioenergetics
- approach: experimental assay
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