R. Parker

Human Heart Failure Alters Mitochondria and Fiber 3D Structure Triggering Metabolic Shifts

This study identifies structural and metabolic changes in human heart failure using SBF-SEM and metabolomic analyses.

Post-transcriptional control contributes to hypoxia induced tumorigenic phenotypes in macrophages

This study shows hypoxia alters macrophage gene expression through increased mRNA decay, leading to tumorigenic phenotypes.

Interferon-α promotes neo-antigen formation andpreferential HLA-B-restricted antigen presentation in pancreatic β-cells

This study shows that IFN-α increases HLA-B-restricted antigen presentation in pancreatic β-cells, potentially influencing T1D pathogenesis.

Cardiovascular Hemodynamics in Mice with Tumor Necrosis Factor Receptor - Associated Factor 2 Mediated Cytoprotection in the Heart

This study evaluates global cardiac function in mice with cardiac-restricted TRAF2 overexpression, finding diminished cardiac function despite reported tolerance to ischemic insults.

Quantitative reconstitution of yeast RNA processing bodies

This study reconstitutes yeast RNA processing bodies from purified components, showing that their composition and dynamics can be recapitulated quantitatively.

Identification of neoantigens in esophageal adenocarcinoma

This study identifies neoantigens in esophageal adenocarcinoma, finding one directly presented HLA-I neoantigen and a predicted HLA-II neoantigen with T-cell responses, highlighting challenges in neoantigen detection.

RNase L-mediated RNA decay alters 3' end formation and splicing of host mRNAs

This study shows that RNase L-mediated RNA decay causes RNA-binding proteins to shift from cytoplasm to nucleus, altering splicing and 3' end formation of host mRNAs, especially interferons.

dsRNA-induced condensation of antiviral proteins promotes PKR activation

The paper shows that dsRNA induces the formation of cytosolic condensates (dRIFs) that enhance PKR activation, leading to translational arrest and stress granule formation.

RNA is required for the maintenance of multiple cytoplasmic and nuclear membrane-less organelles.

The paper degrades RNA in the cytoplasm or nucleus to assess its role in maintaining RNP granules, finding that most are affected while some remain unchanged.

Rapid decay of host basal mRNAs during SARS-CoV-2 infection perturbs host antiviral mRNA biogenesis and export

This study shows SARS-CoV-2 infection inhibits IFN mRNA biogenesis and export by blocking nuclear-cytoplasmic transport and triggering mRNA degradation.

RNase L limits host and viral protein synthesis via inhibition of mRNA export

The paper shows RNase L inhibits viral protein synthesis by blocking mRNA export rather than degrading viral mRNA, and regulates antiviral cytokine production.

Dual Dean entrainment with volume ratio modulation for efficient co-encapsulation: Extreme single-cell indexing

This paper introduces Pirouette-seq, a method for efficient single-cell co-encapsulation with improved throughput and signal-to-noise ratio.

The CXCR6/CXCL16 axis links inflamm-aging to disease severity in COVID-19 patients

This study examines the role of the CXCR6/CXCL16 axis in severe COVID-19, finding elevated CD8+CXCR6+ T cells with age and increased CXCL16 levels in severe cases.

Mapping the SARS-CoV-2 spike glycoprotein-derived peptidome presented by HLA class II on dendritic cells

The paper identifies HLA-II-bound peptides from SARS-CoV-2 spike protein presented by dendritic cells, revealing glycan trimming and a receptor-binding motif-rich region for vaccine design.

Spatially discrete signalling niches regulate fibroblast heterogeneity in human lung cancer

The paper identifies fibroblast subpopulations in lung cancer using single-cell RNA sequencing and shows their spatial distribution and regulation by TGF-β1 and IL-1.

The NAD Metabolome is Functionally Depressed in Patients Undergoing Liver Transplantation for Alcohol-related Liver Disease

This study quantifies the NAD+ metabolome in human liver samples from patients with alcohol-related liver disease and finds reduced NAD+ and precursor levels associated with disease activity.

A quantitative inventory of yeast P body proteins reveals principles of compositional and specificity

The paper quantifies yeast P body protein concentrations, finding only 7 proteins are highly concentrated, while others are lower, and shows sequence elements drive Dcp2 localization.

Modulation of RNA condensation by the DEAD-box protein eIF4A

This study shows that eIF4A reduces RNA condensation and limits stress granule formation in cells by inhibiting RNA-RNA interactions.

Norovirus infection results in assembly of virus-specific G3BP1 granules and evasion of eIF2α signaling.

This study shows that norovirus infection leads to the formation of virus-specific granules and disrupts eIF2α signaling to evade host stress responses.

RNase L reprograms translation by widespread mRNA turnover escaped by antiviral mRNAs

The paper shows RNase L reprograms translation by degrading most mRNAs but allowing antiviral mRNAs like IFN-β to escape degradation during dsRNA stress.

Riboglow: a multicolor riboswitch-based platform for live cell imaging of mRNA and small non-coding RNA in mammalian cells

The paper introduces Riboglow, a multicolor riboswitch-based platform for live cell imaging of mRNA and small non-coding RNA in mammalian cells, showing it outperforms existing methods with a smaller RNA tag.

Intrinsically disordered regions contribute promiscuous interactions to RNP granule assembly

The paper shows that intrinsically disordered regions contribute promiscuous interactions to RNP granule assembly, working with specific interactions to form large cellular structures.