Phytochemical screening, antioxidant properties and antihyperlipidemic activity of Chrysobalanus icaco L. seeds

Chrysobalanus icaco L. (Chrysobalanaceae) is a widely utilized local spice prevalent in the coastal region of the Niger Delta. C. icaco seeds are traditionally documented for their therapeutic applications in treating various conditions, including chronic hyperlipidemia, diabetes, and hemorrhage. This study aimed to investigate the phytochemical, antioxidant, and antihyperlipidemic properties of C. icaco seed extract. Phytochemical analysis identified 16 secondary metabolites in the crude extract. Extract of C. icaco demonstrated a reduction in total cholesterol, triglycerides, low-density lipoproteins (LDL), and very low-density lipoproteins (VLDL) levels, and an increase in high-density lipoprotein (HDL) level within the treatment groups relative to the negative control group. Anti-hyperlipidemic activity confirmed the traditional use of C. icaco in lowering cholesterol levels.