Medicinal Plant Research

The Anti-Cancer Effects of Selected Indigenous Medicinal Plants of the Arid Bioregion

This study evaluates the antioxidant, anti-inflammatory, and antiproliferative activities of extracts from seven Australian Indigenous medicinal plants, finding distinct bioactivities with potential relevance to anticancer drug discovery.

Potential of Korean Forest Tree Seed Extracts as Multifunctional Bioresources: Evaluation of Antioxidant, Anti-inflammatory, Whitening, and Anticancer Activities

Mechanistic Insights into the Inhibition of Recombinant Hepatitis E Virus Papain-like Cysteine Protease by Khaya grandifoliola Hydro-Ethanolic Extract: UHPLC-MS Profiling, Enzyme Kinetics, Computational Modeling, and Cell-Based Assays

This study identifies Khaya grandifoliola hydro-ethanolic extract as a potent inhibitor of HEV-PLpro protease, with anti-HEV activity comparable to ribavirin and no cytotoxicity.

Differential Induction of Cancer Cell Death by Root, Leaf, and Flower Extracts derived from Kalanchoe pinnata

This study evaluates the effects of root, leaf, and flower extracts from Kalanchoe pinnata on colon cancer cell death, finding that root extract induces cell death more effectively than others.

Antiproliferative Activity, Phytochemistry, Network Pharmacology, Molecular Docking and Gene Expression Analysis of Maerua edulis Extracts against Human Cervical Cancer Cell Line

This study evaluates the antiproliferative effects of Maerua edulis extracts on HeLa cells, identifies key phytochemicals, and shows their impact on gene expression related to apoptosis and cell cycle regulation.

Historical texts as a potential resource for plant-derived natural products against SARS-CoV-2 - the example of the Receptarium of Burkhard III von Hallwyl from 16th century Switzerland

This study screens historical plant recipes for antiviral activity against SARS-CoV-2, identifying four plant extracts with significant antiviral effects.

Multimodal antioxidant and anti-inflammatory activity of Rauwolfia serpentina root extracts in experimental models

This study evaluates the antioxidant and anti-inflammatory effects of Rauwolfia serpentina root extracts in immune models, showing extraction-dependent activity and partial mediation by reserpine through oxidative stress and inflammatory pathways.

Gastroprotective Effects of Aleurites moluccanus (Candlenut) Oil Against Aspirin-Induced Gastric Injury in Rats: A Dose-Dependent Histopathological Evaluation

Activities of aqueous extract of Tamarindus indica on phenylhydrazine-induced hematopathological changes in anemic male wistar rats

This study evaluates the effects of Tamarindus indica pulp extract on hemolytic anemia induced by phenylhydrazine in rats, showing improved hematopoiesis and reduced anemia markers.

Exploration of diuretic potential of different parts (flower, bark, leaf) of Butea Monosperma

This study identifies diuretic compounds in different parts of Butea monosperma and demonstrates their diuretic activity in rats, supporting traditional use for hypertension management.

In vitro anti-cancer properties of a commercially available polyherbal nutraceutical (Vernolac) capsule on cancer stem cell-like (NTERA-2 cl.D1) cells.

This study evaluates the anti-cancer effects of Vernolac extract on NTERA-2 cl.D1 cancer stem-like cells, showing significant cytotoxicity and apoptosis induction with minimal impact on non-cancerous cells.

The Growth Inhibitory study of Methanol Extract and Fractions of Seeds of Chrysobalanus icaco (Chrysobalanceae)

This study evaluates the growth inhibitory effects of Chrysobalanus icaco seed extract and its fractions on Sorghum bicolor radicle growth, finding significant anti-proliferative activity linked to phytochemicals.

Chemo-Profiling by UPLC-QTOF-MS, GC-MS/MS analysis and In Vitro Bioactivity Assessment of Desmodium gangeticum DC.

This study profiles the chemical and bioactive compounds in different parts of Desmodium gangeticum and finds leaves contain more bioactive compounds than roots, suggesting leaves as a sustainable alternative for medicinal use.

Hylocereus polyrhizus peel extract restricts DMBA- Croton oil induced skin carcinogenesis: An integrated in vivo and in silico approach

This study evaluates the chemopreventive effects of Hylocereus polyrhizus peel extract against skin carcinogenesis using in vivo and in silico methods, showing reduced tumor burden and inflammation.

Phytochemical Screening, Radical Scavenging and Antimicrobial Activities of the Crude Ethanolic, Methanolic, Ethyl Acetate and Chloroform Leaf Extracts of Arayat Pitogo (Cycas riuminiana Porte ex Regel)

This study evaluates the phytochemical, antioxidant, and antimicrobial properties of four leaf extracts from Cycas riuminiana, finding ethanol and ethyl acetate extracts most effective for antioxidant and antimicrobial activities.

Ethanolic leaf extract of Cleome spinosa induces apoptosis in Ehrlich ascites carcinoma cells through upregulation of p53 and down-regulation of Bcl-xL in vitro and in vivo

Impact of Capsicum frutescens (L.) fruit ethanol extract on H+/K+ ATPase activity, Gastrin hormone, Parietal cells, and ulcer index in ibuprofen- induced gastric ulcers: A Wistar rat model.

This study evaluates the effect of Capsicum frutescens ethanol extract on gastric ulcer parameters in ibuprofen-induced ulcers in rats, finding reduced ulcer index, H+/K+ ATPase activity, gastrin levels, and parietal cell count.

Methanol Crude Extract of Litsea Monopetala Leaves combats oxidative stress, clot formation, inflammation and stool frequency in Animal Model

This study evaluates the antioxidant, thrombolytic, analgesic, and antidiarrheal effects of a methanolic extract from Litsea monopetala leaves in animal models.

Evaluation of Antioxidant Anticancer and Antimicrobial Activities of Datura Leaf Extracts: A Microbiological Perspective

This study evaluates the antioxidant and antimicrobial activities of Datura leaf extracts using in vitro assays, showing significant properties that support their potential as natural alternatives to synthetic agents.

Phytochemical screening, analgesic, anti-pyretic and antibacterial potentials of Litsea glutinosa (L) leaves extracts in vivo and in vitro technique

This study evaluates the analgesic, antipyretic, and antibacterial properties of Litsea glutinosa leaf extracts using in vivo and in vitro methods, finding significant pain inhibition and bacterial growth suppression.

Antiviral activity of rosemary extract against Zika virus in human dermal fibroblasts

This study investigates the antiviral activity of rosemary extract and its components against Zika virus in human dermal fibroblasts, showing virucidal effects and interference with post-entry replication stages.

Potential antiviral and immunomodulatory Amazonian medicinal plant compounds

This study evaluates antiretroviral and immunomodulatory activity of Amazonian plant extracts against HIV, identifying potential compounds for therapeutic applications.

THE PHYTOPHARMACOLOGICAL EVALUATION OF THE METHANOL ROOT EXTRACT OF AZANZA GARCKEANA (MALVACEAE) ON ISOLATED WISTAR RAT UTERINE SMOOTH MUSCLES.

This study evaluates the uterotonic activity of a methanol root extract from Azanza garckeana on isolated rat uterine smooth muscles, identifying a glycoside-related compound as the active constituent.

Erythropoietic, hematinic and leucocytic activities of the aqueous extracts of the fruits and leaves of Solanum torvum

This study evaluates the erythropoietic, hemanitic, and leucocytic effects of Solanum torvum aqueous extracts in rabbits, finding significant increases in blood parameters.

Anti-SARS-CoV-2 potential of Cissampelos pareira L. identified by Connectivity map-based analysis and in vitro studies

The paper identifies potential anti-SARS-CoV-2 compounds from Cissampelos pareira L. using connectivity map analysis and in vitro testing, showing high inhibition of viral replication.

Antiproliferative Effect of Epilobium parviflorum Extracts on Colorectal Cancer Cell Line HT-29

This study shows that aqueous and ethanolic Epilobium parviflorum extracts reduce HT-29 colon cancer cell viability and induce apoptosis without significantly affecting non-cancerous BJ cells.

Transcriptome analysis and connectivity mapping of Cissampelos pareira L. provides molecular links of ESR1 modulation to viral inhibition

This study identifies molecular links between ESR1 modulation and viral inhibition through transcriptome analysis of Cissampelos pareira extract in MCF7 cells.

Investigation of biological activities of Colocasia gigantea Hook.f. leaves and PASS prediction, in silico molecular docking with ADME/T analysis of its isolated bioactive compounds

This paper investigates the antidiarrheal, antimicrobial, and antioxidant properties of Colocasia gigantea extract and performs in silico molecular docking analysis of its bioactive compounds.

Deciphering the molecular pathways of apoptosis using leaf extract of Basella alba against Ehrlichs Ascites Carcinoma (EAC) cell line in Swiss albino mice model

This study investigates the apoptotic effects of Basella alba leaf extracts on Ehrlich's Ascites Carcinoma cells using various bioassays and finds that the extracts induce apoptosis via both extrinsic and intrinsic pathways.