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BioinformaticsGenome biology
Peer-reviewed journal article

REPIC: A database for exploring N6-methyladenosine methylome

Shun LiuiD, Allen C. ZhuiD, Chuan HeiD, Mengjie CheniD

Abstract

The REPIC (RNA Epitranscriptome Collection) database records about 10 million peaks called from publicly available m6A-seq and MeRIP-seq data using our unified pipeline. These data were collected from 672 samples of 49 studies, covering 61 cell lines or tissues in 11 organisms. REPIC allows users to query N6-methyladenosine (m6A) modification sites by specific cell lines or tissue types. In addition, it integrates m6A/MeRIP-seq data with 1,418 histone ChIP-seq and 118 DNase-seq data tracks from the ENCODE project in a modern genome browser to present a comprehensive atlas of m6A, histone modification sites and chromatin accessibility regions. REPIC is accessible at http://epicmod.uchicago.edu/repic.

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