plot2DO: a tool to assess the quality and distribution of genomic data

SummaryMicrococcal nuclease digestion followed by deep sequencing (MNase-seq) is the most used method to investigate nucleosome organization on a genome-wide scale. We present plot2DO, a software package for creating 2D occupancy plots, which allows biologists to evaluate the quality of MNase-seq data and to visualize the distribution of nucleosomes near the functional regions of the genome (e.g. gene promoters, origins of replication, etc.).\n\nAvailability And ImplementationThe plot2DO open source package is freely available on GitHub at https://github.com/rchereji/plot2DO under the MIT license.\n\nContactrazvan.chereji@nih.gov\n\nSupplementary InformationSupplementary data are available at Bioinformatics online.