bioRxivImmunology
Immunological features that determine the strength of antibody responses to BNT162b2 mRNA vaccine against SARS-CoV-2
T. Kageyama, S. Tanaka, K. Etori, K. Hattori, K. Miyachi, T. Kasuya, T. Iwamoto, K. Ikeda, H. Igari, K. Yokote, H. Nakajima
Abstract
We analyzed peripheral blood mononuclear cells (PBMCs) of each 20 individuals with a high anti-SARS-CoV-2 antibody titer and a low antibody titer out of 1,774 healthcare workers who received BNT162b2 mRNA vaccine. A higher antibody titer was associated with the frequencies of naive and transitional B cells before vaccination. In addition, fold changes in the frequency of activated CD8+ T cells upon vaccination were correlated with the antibody titers.
- organism: human
- assay: bulk RNA-seq
- research focus: host-pathogen & immune response
- approach: experimental assay
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