S. Tanaka

Impact of body image on the kinematics of gait initiation

This study examines how altering body image affects gait initiation kinematics, finding increased stride length, step completion time, and foot lift height when participants imagine their bodies becoming larger.

HD-ZIP IV genes are essential for embryo initial cell polarization in the radial axis initiation in Arabidopsis

This study identifies HD-ZIP IV genes as essential for radial axis formation in Arabidopsis by regulating apical cell polarization and division orientation.

Virological characteristics of the SARS-CoV-2 Omicron EG.5.1 variant

The paper investigates the virological features of the SARS-CoV-2 EG.5.1 variant, finding its fitness and antiviral sensitivity comparable to XBB.1.5, with structural differences in spike proteins.

Akaluc bioluminescence offers superior sensitivity to track in vivo dynamics of SARS-CoV-2 infection

This study introduces AkaBLI, a method using Akaluc bioluminescence to track SARS-CoV-2 infection in vivo with higher sensitivity than NanoLuc, showing its utility in monitoring viral dynamics and vaccine efficacy.

Virological characteristics of the SARS-CoV-2 XBB.1.5 variant

The paper analyzes the virological characteristics of the SARS-CoV-2 XBB.1.5 variant, showing reduced pathogenicity and impaired MHC expression due to mutations in ORF8 and S.

Upregulated Fcrl5 disrupts B cell anergy and causes autoimmunity

This study shows that upregulated Fcrl5 disrupts B cell anergy, leading to autoimmunity by activating autoreactive B cells and exacerbating autoimmune disease models.

Intratumoral administration of recombinant murine interleukin-12 prevents tumor progression and bone invasion

This study shows that intratumoral IL-12 injection reduces tumor growth and bone resorption in a mouse model of oral squamous cell carcinoma through a T cell-dependent mechanism.

Senescence triggers intracellular acidification and lysosomal alkalinization via ATP6AP2 attenuation in breast cancer cells

This study shows that ATP6AP2 downregulation in senescent breast cancer cells causes pH dysregulation, impairing lysosome function and altering immune responses.

Direction and distance dependency of reaching movements of lower limb

This study examines lower limb reaching movements, finding that contralateral movements are slower due to delayed toe movement onset and altered joint activation patterns.

Anesthetic-Binding Induced Motion of GABA A Receptors Revealed by Coarse-Grained Molecular Dynamics Simulations

This study uses coarse-grained molecular dynamics simulations to analyze how anesthetic binding affects the motion of GABAA receptors, revealing characteristic pore motion related to gate-opening.

Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

This study identifies XBB as a SARS-CoV-2 variant resulting from recombination of BA.2 subvariants, showing increased resistance to neutralizing antibodies and enhanced fusogenicity compared to BA.2.75.

Non-micelle-like Amyloid Aggregate Stabilizes Amyloid β (1-42) Growth Nuclei Formation

This study uses molecular dynamics simulations to show that non-micelle-like Aβ42 aggregates stabilize growth nuclei formation by thermodynamically binding monomers to the growth edge.

Convergent evolution of the SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant

The paper investigates convergent evolution in SARS-CoV-2 Omicron subvariants, identifying five critical spike protein substitutions in BQ.1.1 that enhance viral fitness and antibody resistance.

Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5

This study compares the pathogenicity of SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.5, finding BA.5 is more fusogenic and induces stronger inflammation than earlier variants.

Virological characteristics of the SARS-CoV-2 Omicron BA.2.75

This study investigates the virological characteristics of SARS-CoV-2 Omicron BA.2.75, finding it has higher transmissibility and pathogenicity compared to BA.2 and BA.5, but similar sensitivity to antiviral drugs.

Virological characteristics of the novel SARS-CoV-2 Omicron variants including BA.2.12.1, BA.4 and BA.5

This study analyzes the virological characteristics of SARS-CoV-2 Omicron variants BA.2.12.1, BA.4, and BA.5, finding they have higher reproduction numbers, reduced neutralization by prior immunity, increased replication in lung cells, and greater pathogenicity in hamsters compared to BA.2.

Engineering of an electrically charged hydrogel implanted into a traumatic brain injury model for stepwise neuronal tissue reconstruction

The paper describes a two-step method using charged hydrogels and neural stem cell injection to promote brain tissue reconstruction after traumatic injury.

Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium

This study identifies Semaphorin 3G as a factor that worsens joint inflammation by promoting macrophage accumulation and proliferation in RA synovium.

Computational Prediction of Heteromeric Protein Complex Disassembly Order with Hybrid Monte Carlo/Molecular Dynamics Simulation

The paper develops a hybrid Monte Carlo/Molecular Dynamics method to predict disassembly orders of heteromeric protein complexes with high accuracy.

Genetically-linked simultaneous overexpression of multiple herbicide-metabolizing genes for broad-spectrum resistance in an agricultural weed Echinochloa phyllopogon

The paper identifies genetically linked overexpression of multiple herbicide-metabolizing genes in E. phyllopogon, enhancing and broadening metabolic resistance to multiple herbicides.

Heteologous saRNA-Prime, DNA Dual-Antigen-Boost SARS-CoV-2 Vaccination Elicits Robust Cellular Immunogenicity and Cross-Variant Neutralizing Antibodies

This study evaluates heterologous vaccination with two SARS-CoV-2 vaccines in mice, finding enhanced humoral and T-cell responses and broad neutralizing activity against variants.

Rapid Identification of Neutralizing Antibodies against SARS-CoV-2 Variants by mRNA Display

This study uses mRNA display to identify and engineer neutralizing antibodies against SARS-CoV-2 variants, revealing binding modes and demonstrating their effectiveness against mutations in the spike protein.

Desiccation-induced fibrous condensation of CAHS protein from an anhydrobiotic tardigrade

This study investigates the self-assembling properties of CAHS1 protein from tardigrades under desiccation conditions, showing it forms hydrogels and condensates that may contribute to desiccation tolerance.

Immunological features that determine the strength of antibody responses to BNT162b2 mRNA vaccine against SARS-CoV-2

The paper identifies immunological features, including B cell frequencies and CD8+ T cell activation, that correlate with antibody response strength to the BNT162b2 mRNA vaccine.

Elucidating Microscopic Events Driven by GTP Hydrolysis Reaction in Ras-GAP System with Semi-reactive Molecular Dynamics Simulation: Alternative Role of Phosphate Binding Loop as Mechanical Energy Storage

The paper uses molecular dynamics simulations to show that GTP hydrolysis in the Ras-GAP system stores mechanical energy in the P-loop through steric interactions, challenging the Coulomb repulsion hypothesis.

The Dual-Antigen Ad5 COVID-19 Vaccine Delivered as an Intranasal Plus Subcutaneous Prime Elicits Th1 Dominant T-Cell and Humoral Responses in CD-1 Mice

This study evaluates a dual-antigen Ad5 vaccine delivered via subcutaneous and intranasal routes in mice, showing that combined prime-only delivery elicits strong humoral and T-cell responses against SARS-CoV-2.

A recombinant ACE2 Triple Decoy that traps and neutralizes SARS-CoV-2 shows enhanced affinity for highly transmissible SARS-CoV-2 variants

The paper develops an ACE2 Triple Decoy that maintains high affinity for SARS-CoV-2 variants and shows enhanced affinity for specific mutations.

Remarked Suppression of Aβ42 Protomer-protomer Dissociation Reaction via Pentamer Dimerization Elucidated by Molecular Dynamics Simulation

This study uses molecular dynamics simulations to show that pentamer dimerization of Aβ42 suppresses protomer dissociation, potentially slowing amyloid fibril growth.

Asymbiotic mass production of the arbuscular mycorrhizal fungus Rhizophagus clarus

This study shows that combining strigolactone and methyl jasmonate with myristate and organic nitrogen in asymbiotic cultures of Rhizophagus clarus HR1 increases spore production and infectivity, supporting plant growth.

Robotic Multi-Probe-Single-Actuator Inchworm Neural Microdrive

This paper introduces a robotic multi-probe-single-actuator neural microdrive using phase-change-material micro-grippers for precise electrode placement in rat hippocampus.