Nature NeuroscienceNeurosciencePeer-reviewed journal article
A genetically encoded GRAB sensor for measuring serotonin dynamics in vivo
Jinxia WaniD, Wanling PengiD, Xuelin LiiD, Tongrui QianiD, Kun SongiD, Jianzhi ZengiD, Fei DengiD, Suyu Hao, Jiesi FengiD, Peng Zhang, Yajun ZhangiD, Jing ZouiD, Sunlei Pan, Mimi ShiniD, B. Jill VentoniD, Jie ZhuiD, Miao JingiD, Min XuiD, Yulong LiiD
Abstract
Serotonin (5-HT) is a phylogenetically conserved monoamine neurotransmitter modulating a variety of processes in the brain. To directly visualize the dynamics of 5-HT, we developed a genetically encoded GPCR-Activation-Based 5-HT (GRAB5-HT) sensor with high sensitivity, selectivity, and spatiotemporal resolution. GRAB5-HT, detected 5-HT release in multiple physiological and pathological conditions in both flies and mice, and thus provides new insights into the dynamics and mechanisms of 5-HT signaling.
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