Jiesi Feng

This study shows that peri-LC neurons regulate bone endothelial heterogeneity and density through norepinephrine signaling in enriched environments.

The paper develops red-shifted GRAB acetylcholine sensors for multiplex imaging of ACh and other neuromodulators in vivo with high spatiotemporal resolution.

The paper develops methods to infer norepinephrine dynamics from partial observations, revealing temporal patterns during arousal.

This study shows serotonin modulates the time window for fear learning by regulating neuronal activity in the ventral hippocampus.

This study investigates how phase synchrony between prefrontal noradrenergic and cholinergic signals relates to inhibitory control in mice.

The paper reveals how locus coeruleus-norepinephrine neurons organize to regulate brain-wide neural dynamics through region-specific axon projections and synchronized firing.

This study identifies a stress-induced positive feedback loop in the LHb-LC axis mediated by astrocytic calcium signaling, which influences depressive-like behaviors in mice.

This study uses two-photon microscopy to show that NE and ACh transients have distinct spatiotemporal dynamics during decision-making in mice, with NE promoting exploration.

This study shows that prolonged norepinephrine release in the dentate gyrus during stress aids in contextual disambiguation without a salient aversive stimulus.

The paper investigates how spatiotemporal dynamics of norepinephrine release in the prefrontal cortex affect neuronal firing and finds that local NE fields can drive cell firing independently of global fields during decoupling.

The paper investigates how catecholamine signaling is affected by activity levels, showing that high tonic activity reduces phasic transmission and desensitizes responses.

The paper investigates neuromodulator dynamics in mice during a naturalistic reward-threat task, finding distinct roles for norepinephrine, dopamine, and serotonin in encoding motivational states.

This paper develops improved GRABNE sensors to monitor norepinephrine release in vivo with high sensitivity and uses them to study NE dynamics in mice.

This paper develops dual-color GRAB sensors to monitor spatiotemporal serotonin release in vivo, revealing uniform and gradient release patterns and seizure-induced waves.

This study identifies norepinephrine as a threat prediction error signal during fear learning, contrasting with dopamine's role in reward prediction.

GESIAP is a MATLAB-based image analysis program that processes genetically encoded sensor data to analyze neuromodulator transmission properties across cell types and species.

This study investigates how locus coeruleus-norepinephrine system activity and astrocytic responses change during sleep states, revealing dynamic fluctuations in norepinephrine levels and their relationship to sleep processes.

This study shows astrocytes regulate NMDAR tone through Best1-mediated glutamate and D-serine release, which is essential for cognitive flexibility and memory repotentiation during reversal learning.

This paper develops a genetically encoded sensor to measure serotonin dynamics in vivo, showing its effectiveness in both flies and mice across various conditions.

The paper develops and optimizes GRABDA fluorescent sensors to monitor dopaminergic activity with high sensitivity and resolution in vivo.

The paper develops GRABNE sensors for rapid, specific in vivo detection of norepinephrine, demonstrating their use in various experimental contexts.

This paper develops GACh sensors, genetically-encoded fluorescent indicators for acetylcholine, validated across multiple cell types and species, revealing new insights into cholinergic transmission.

This paper develops GRABDA sensors to measure dopamine with high precision in multiple organisms during complex behaviors.