Min Xu

stk32a links sleep homeostasis to suppression of sensory and motor systems

This study identifies stk32a as a conserved sleep regulator that links neuropeptidergic signaling to sleep homeostasis by suppressing sensory and motor systems in zebrafish and mice.

Cell-type specific optogenetic fMRI on basal forebrain reveals functional network basis of behavioral preference

The paper uses optogenetic fMRI in mice to show how specific basal forebrain neuron types influence whole-brain BOLD activations and behavioral preferences.

A toolkit of highly selective and sensitive genetically encoded neuropeptide sensors

The paper develops GRAB sensors for detecting neuropeptides with high specificity and sensitivity, enabling in vivo monitoring of their release and function.

Projectome-defined subtypes and modular intra-hypothalamic subnetworks of peptidergic neurons

The paper identifies 31 projectome-defined subtypes of hypothalamic neurons and six modular subnetworks, revealing the organization of axon projections and their functional roles.

A GRAB sensor reveals activity-dependent non-vesicular somatodendritic adenosine release

The paper develops a genetically encoded adenosine sensor to show activity-dependent non-vesicular adenosine release from somatodendritic regions via calcium influx and equilibrative transporters.

A high-performance genetically encoded fluorescent indicator for in vivo cAMP imaging

This paper develops a new genetically encoded fluorescent cAMP indicator, G-Flamp1, which shows high sensitivity, brightness, and fast response kinetics for in vivo cAMP imaging.

Whole-brain in vivo base editing reverses autistic-like behaviors in mice

This paper demonstrates whole-brain in vivo base editing in mice to reverse autistic-like behaviors by correcting a mutation in the MEF2C gene.

A genetically encoded GRAB sensor for measuring serotonin dynamics in vivo

This paper develops a genetically encoded sensor to measure serotonin dynamics in vivo, showing its effectiveness in both flies and mice across various conditions.

An optimized acetylcholine sensor for monitoring in vivo cholinergic activity

The paper develops an optimized GRABACh sensor to measure in vivo cholinergic activity in Drosophila and mice, revealing compartmental ACh signals and single-trial dynamics.

Highly efficient and super-bright neurocircuit tracing using vector mixing-based virus cocktail

This paper introduces MAP-ENVIVIDERS, a vector mixing-based virus cocktail that significantly improves neurocircuit tracing efficiency and sensitivity compared to existing methods.

A genetically-encoded fluorescent sensor enables rapid and specific detection of dopamine in flies, fish, and mice

This paper develops GRABDA sensors to measure dopamine with high precision in multiple organisms during complex behaviors.