Miao Jing

Astrocyte-to-microglia purinergic signaling mediates synaptic shielding and promotes neuronal activity

The paper identifies astrocyte-to-microglia purinergic signaling as a mechanism converting neuronal hypoactivity into synapse-selective microglial regulation of circuit activity.

An axonal brake on striatal dopamine output by cholinergic interneurons

This study shows that cholinergic interneurons in the striatum use nicotinic receptors to limit dopamine release by depressing axonal depolarization and calcium summation.

Spatiotemporally selective ATP events from astrocytes encode injury information and guide sustained microglial response

The paper identifies Inflares, spatiotemporally selective ATP events from astrocytes, which encode injury information and guide microglial response, showing their role in both injury amplification and therapeutic reversal.

Reward contingency gates selective cholinergic suppression of amygdala neurons

This study shows that basal forebrain cholinergic activation modulates amygdala neuron activity based on reward contingency, affecting conditioned behavior but not unconditioned responses.

A GRAB sensor reveals activity-dependent non-vesicular somatodendritic adenosine release

The paper develops a genetically encoded adenosine sensor to show activity-dependent non-vesicular adenosine release from somatodendritic regions via calcium influx and equilibrative transporters.

Local 5-HT signal bi-directionally regulates the coincidence time window of associative learning

The paper shows that serotonin signaling modulates the coincidence time window in Drosophila associative learning by a feedback circuit involving ACh and 5-HT.

Dual color mesoscopic imaging reveals spatiotemporally heterogeneous coordination of cholinergic and neocortical activity.

The paper uses dual-color mesoscopic imaging in awake mice to show that cholinergic and cortical activity are spatiotemporally heterogeneous and linked to behavioral states.

GESIAP: A Versatile Genetically Encoded Sensor-based Image Analysis Program

GESIAP is a MATLAB-based image analysis program that processes genetically encoded sensor data to analyze neuromodulator transmission properties across cell types and species.

Microglia undergo rapid phenotypic transformation in acute brain slices but remain essential for neuronal synchrony

The paper investigates how microglia change their phenotype in acute brain slices and how these changes affect neuronal network activity.

Associative learning drives longitudinally-graded presynaptic plasticity of neurotransmitter release along axonal compartments

The paper shows that associative learning induces compartmentalized, bidirectional plasticity of acetylcholine release in Drosophila mushroom body axons, with valence-dependent effects and distinct molecular mechanisms.

An ultrasensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo

The paper develops an ultrasensitive GRABATP1.0 sensor to detect extracellular ATP in real time, demonstrating its use in vitro and in vivo across multiple conditions.

Goal-directed motor actions drive acetylcholine dynamics in sensory cortex

This study shows that acetylcholine dynamics in sensory cortex are driven by goal-directed motor actions rather than sensory cues or rewards during task learning.

A genetically encoded GRAB sensor for measuring serotonin dynamics in vivo

This paper develops a genetically encoded sensor to measure serotonin dynamics in vivo, showing its effectiveness in both flies and mice across various conditions.

An optimized acetylcholine sensor for monitoring in vivo cholinergic activity

The paper develops an optimized GRABACh sensor to measure in vivo cholinergic activity in Drosophila and mice, revealing compartmental ACh signals and single-trial dynamics.

Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances learning of cue-reward contingency

The paper shows that acetylcholine in the basolateral amygdala increases during reward-related events and enhances learning of cue-reward associations in mice.

Rapid 'multi-directed' cholinergic transmission at central synapses

This study demonstrates that acetylcholine (ACh) signaling at retinal synapses exhibits both synaptic and non-synaptic transmission characteristics, with rapid currents and limited spread.

Basal forebrain-derived acetylcholine encodes valence-free reinforcement prediction error.

Cholinergic basal forebrain neurons and cortical acetylcholine release encode an unsigned, valence-free reinforcement prediction error that tracks learning alongside dopamine via shared upstream circuits.

A genetically encoded fluorescent sensor for rapid and specific in vivo detection ofnorepinephrine

The paper develops GRABNE sensors for rapid, specific in vivo detection of norepinephrine, demonstrating their use in various experimental contexts.

A genetically-encoded fluorescent sensor enables rapid and specific detection of dopamine in flies, fish, and mice

This paper develops GRABDA sensors to measure dopamine with high precision in multiple organisms during complex behaviors.