bioRxivCell BiologyPreprint
Single-cell RNA Expression of SARS-CoV-2 Cell Entry Factors in Human Endometrium during Preconception
F. Vilella Mitjana, W. Wang, I. Moreno Gimeno, S. Quake, C. Simon
Abstract
We investigated potential SARS-CoV-2 tropism in human endometrium by single-cell RNA-sequencing of viral entry-associated genes in healthy women. Percentages of endometrial cells expressing ACE2, TMPRSS2, CTSB, or CTSL were <2%, 12%, 80%, and 80%, respectively, with 0.7% of cells expressing all four genes. Our findings imply low efficiency of SARS-CoV-2 infection in the endometrium before embryo implantation, providing information to assess preconception risk in asymptomatic carriers.
- organism: human
- assay: scRNA-seq
- research focus: cell type annotation
- research focus: differential expression
- approach: experimental assay
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Female reproductive tract has low concentration of SARS-CoV2 receptors
Jyoti Goad, Joshua D. Rudolph, Aleksandar Rajkovic·PLoS ONEPeer-reviewed·Dec 14, 2020
- SARS-CoV-2 Can Infect Human Embryos
Mauricio Montaño, Andrea R. Victor, … Manuel Viotti·Scientific ReportsPeer-reviewed·Sep 14, 2022
- Comprehensive evaluation of ACE2 expression in female ovary by single-cell RNA-seq analysis
Siming Kong, Zhiqiang Yan, … Jie Qiao·bioRxiv·Feb 23, 2021
- SARS-CoV-2 Viral Pseudoparticles Preferentially Infect Ectoderm In Human Embryonic Tissues
Ann Song, Prue Talbot·Frontiers in Cell and Developmental BiologyPeer-reviewed·Apr 7, 2026
- A single-cell RNA expression map of human coronavirus entry factors
Manvendra Singh, Vikas Bansal, Cédric Feschotte·Cell ReportsPeer-reviewed·Sep 1, 2020
- Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?
Roger Piqué-Regi, Roberto J. Romero, … Nardhy Gomez‐Lopez·eLifePeer-reviewed·Jul 13, 2020