bioRxivImmunology
A novel humanized mouse model to study mucosal HIV-1 transmission and prevention
K. Vanshylla, K. Held, T. Eser, H. Gruell, K. Jain, D. Weiland, J. Muench, B. Gruettner, C. Geldmacher, F. Klein
Abstract
Humanized mice have been critical for HIV-1 research, but are inefficient at mucosal HIV-1 transmission. We present a fetal tissue-independent model called CD34T+ with enhanced human leukocyte levels in the blood and improved T cell homing to the gut-associated lymphoid tissue. CD34T+ mice are highly permissive to intra-rectal HIV-1 infection, which can be prevented by infusion of broadly neutralizing antibodies. Therefore, CD34T+ mice provide a novel platform for mucosal HIV-1 transmission and prevention studies.
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Novel GVHD resistant humanized-PBMC mouse model for preclinical HIV research
Leo Holguin, Liliana Echavarria Parra, John C. Burnett·bioRxiv·Jun 3, 2021
- Generation of Functional Human T Cell Development in NOD/SCID/IL2rγnull Humanized Mice Without Using Fetal Tissue: Application as a Model of HIV Infection and Persistence
C. Colas, O. Volodina, … E. Haddad·bioRxiv·May 30, 2022
- Humanized FLT3 mice display enhanced tissue engraftment and support HIV-1 persistence and rebound
Patricia Resa‐Infante, Patricia Pinol, … Javier Martínez‐Picado·Translational researchPeer-reviewed·Aug 12, 2026
- Human microglia extensively reconstitute in humanized BLT mice with human interleukin-34 transgene and support HIV-1 brain infection
J. Zhang, S. C. Lohani, … Q. Li·bioRxiv·Feb 18, 2021
- Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice
C. E. Hioe, G. Li, … L. Su·bioRxiv·May 24, 2021
- μ-Lat: A Mouse Model to Evaluate Human Immunodeficiency Virus Eradication Strategies
H. S. Sperber, P. P. Togarrati, … S. K. Pillai·The FASEB JournalPeer-reviewed·Sep 9, 2020