Author

C. Colas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:mouse· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

E. Haddad· 5 shared Y. Li· 5 shared C. Beausejour· 4 shared J. V. Guimond· 3 shared B. Benabdallah· 2 shared G. Moquin-Beaudry· 2 shared J. Guimond· 2 shared A. Chase· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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5 shared papersCell Biology

E. Haddad

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Generation of Functional Human T Cell Development in NOD/SCID/IL2rγnull Humanized Mice Without Using Fetal Tissue: Application as a Model of HIV Infection and Persistence

C. Colas, O. Volodina, K. Beland, T. N. Q. Pham, Y. Li, F. Dallaire, C. Soulard, W. Lemieux, A. Colamartino, C. Tremblay-Laganiere, R. Dicaire, J. Guimond, N. Patey, S. Vobecky, N. Poirier, , E. Haddad

This paper introduces a new humanized mouse model using cord blood-derived CD34+ cells and pediatric thymic tissue that supports functional T cell development and HIV infection and persistence.

bioRxiv · May 30, 2022Immunology

Autologous humanized mouse models of iPSC-derived tumors allow for the evaluation and modulation of cancer-immune cell interactions

G. Moquin-Beaudry, B. Benabdalah, D. Maggiorani, O. Le, Y. Li, C. Colas, C. Raggi, B. Ellezam, M. M'Callum, D. Dal Soglio, J. V. Guimond, M. Paganelli, E. Haddad, C. Beausejour

This paper develops autologous humanized mouse models of iPSC-derived tumors to study and modulate cancer-immune interactions, showing immune infiltration and response to PD-1 inhibition.

bioRxiv · Apr 2, 2021Cancer Biology

The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2

A. L. Cathcart, C. Havenar-Daughton, F. A. Lempp, D. Ma, M. Schmid, M. L. Agostini, B. Guarino, J. Di iulio, L. Rosen, H. Tucker, J. Dillen, S. Subramanian, B. Sloan, S. Bianchi, J. Wojcechowskyj, , C. M. Hebner

This paper evaluates the in vitro and in vivo efficacy of dual-action monoclonal antibodies VIR-7831 and VIR-7832 against SARS-CoV-2, showing potent neutralization and reduced viral load in a hamster model.

bioRxiv · Mar 9, 2021 · PreprintImmunology

NK cells prevent the formation of teratomas derived from human induced pluripotent stem cells

B. Benabdallah, C. Deslauniers-Langevin, C. Colas, Y. Li, J. Guimond, E. Haddad, C. Beausejour

This study shows that NK cells prevent teratoma formation from hiPSCs in immune competent hosts, while autologous T cells can reject established teratomas.

bioRxiv · Jul 25, 2019Cell Biology

Immune tolerance of human induced pluripotent stem cell-derived myogenic progenitor cells in humanized mice

B. Benabdallah, C. Desaulniers-Langevin, M.-L. Goyer, C. Colas, C. Maltais, Y. Li, J. V. Guimond, J. P. Tremblay, E. Haddad, C. Beausejour

This study evaluates immune tolerance of hiPSC-derived myogenic progenitor cells in humanized mice, finding autologous cells are tolerated while allogeneic grafts are rejected, and NK cell transfer prevents teratoma formation.

bioRxiv · Jul 11, 2019 · PreprintCell Biology

The tumor immune response is not compromised by mesenchymal stromal cells in humanized mice

G. Moquin-Beaudry, C. Colas, Y. Li, R. Bazin, J. V. Guimond, E. Haddad, C. Beausejour

This study shows that human umbilical cord mesenchymal stromal cells do not affect tumor growth or immune rejection in humanized mice.

bioRxiv · Jul 11, 2019Cell Biology