bioRxivBiochemistry
An Antioxidant Enzyme Therapeutic for COVID-19
M. Qin, Z. Cao, J. Wen, Q. Yu, C. Liu, F. Wang, F. Yang, Y. Li, G. A. Fishbein, S. Yan, B. Xu, Y. Hou, Z. Ning, K. Nie, N. Jiang, Z. Liu, J. Wu, Y. Yu, H. Li, H. Zheng, J. Li, W. Jin, S. Pan, S. Wang, J. Chen, , Y. Lu
Abstract
The COVID-19 pandemic has taken a significant toll on people worldwide, and there are currently no specific antivirus drugs or vaccines. We report herein a therapeutic based on catalase, an antioxidant enzyme that can effectively breakdown hydrogen peroxide and minimize the downstream reactive oxygen species, which are excessively produced resulting from the infection and inflammatory process. Catalase assists to regulate production of cytokines, protect oxidative injury, and repress replication of SARS-CoV-2, as demonstrated in human leukocytes and alveolar epithelial cells, and rhesus macaques, without noticeable toxicity. Such a therapeutic can be readily manufactured at low cost as a potential treatment for COVID-19.
- organism: human
- organism: rat
- organism: non-human primate
- research focus: drug response / drug discovery
- approach: experimental assay
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Topoisomerase 1 inhibition therapy protects against SARS-CoV-2-induced inflammation and death in animal models.
J. S. Y. Ho, B. W.-Y. Mok, … Jeya·bioRxiv·Dec 1, 2020
- Hemin shows antiviral activity in vitro, possibly through suppression of viral entry mediators.
M. A. UNAL, C. V. BITIRIM, … A. YILMAZER·bioRxiv·May 24, 2022
- Lung-selective Cas13d-based nanotherapy inhibits lethal SARS-CoV-2 infection by targeting host protease Ctsl
- Amantadine disrupts lysosomal gene expression; potential therapy for COVID19
S. Smieszek, B. Przychodzen, M. H. Polymeropoulos·bioRxiv·Apr 5, 2020
- Alpha-1 antitrypsin inhibits SARS-CoV-2 infection
L. Wettstein, C. Conzelmann, … J. Muench·bioRxiv·Jul 2, 2020
- Zinc pyrithione is a potent inhibitor of PLPro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication
J. Kladnik, A. Dolinar, … I. Turel·bioRxiv·Mar 3, 2022