Biological PsychiatryNeurosciencePeer-reviewed journal article
Reduced Kv3.1 Activity in Dentate Gyrus Parvalbumin Cells Induces Vulnerability to Depression.
Lucian MedrihaniD, Gali UmschweifiD, Anjana Sinha, Shayna ReediD, Jinah Lee, Katherina Gindinova, Subhash C. SinhaiD, Paul GreengardiD, Yotam SagiiD
Abstract
Parvalbumin (PV)-expressing interneurons are important for cognitive and emotional behaviors. These neurons express high level of p11, a protein associated with depression and action of antidepressants. Here we show that either specific deletion of p11 (p11 cKO) or chemogenetic inhibition in dentate gyrus (DG) PV neurons leads to anxiety-like behavior and susceptibility to depression in mice. DG PV neurons from p11 cKO mice showed reduced level and function of Kv3.1, and consequentially reduced capacity of high-frequency firing and altered short-term plasticity at synapses on granule cells. Activation of Kv3.1 or overexpression of the channel attenuated the vulnerability to depressive behavior.
- Citations
- 37
- FWCI
- 3.75
- Field percentile
- top 6%
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Chronic hM3Dq-DREADD mediated chemogenetic activation of parvalbumin-positive inhibitory interneurons in postnatal life alters anxiety and despair-like behavior in adulthood in a task and sex-dependent manner
Toshali Banerjee, Sthitapranjya Pati, … Vidita A. Vaidya·Journal of BiosciencesPeer-reviewed·Dec 7, 2022
- Dysfunctional parvalbumin interneurons in a genetic mouse model of schizophrenia
Sara Hijazi, Maria Pascual-Garcia, … Steven A. Kushner·bioRxiv·Sep 10, 2023
- GluK1 kainate receptors are necessary for functional maturation of parvalbumin interneurons regulating amygdala circuit function
Joni Haikonen, Rakenduvadhana Szrinivasan, … Sari E. Lauri·Molecular PsychiatryPeer-reviewed·Jun 28, 2024
- Dnmt1-deficiency in PV interneurons alters cortical circuit function and leads to depression-like behavior
Jenice Linde, Gerion Nabbefeld, … Geraldine Zimmer‐Bensch·bioRxiv·Sep 28, 2024
- Blockade of Kv3.1 by MK-801, a PCP-Derivative NMDA Receptor Inhibitor: Implications for Models of Schizophrenia
Tae Jun Park, Sang Woong Park, … Young Min Bae·bioRxiv·Sep 13, 2026
- A silent Kv channel subunit shapes PV neuron action potential waveform and short-term synaptic plasticity during high-frequency firing
Sanika Ganesh, Theresa M. Canty, Bernardo Luis Sabatini·Proceedings of the National Academy of SciencesPeer-reviewed·Feb 3, 2026