Author

Lucian Medrihan

Rockefeller UniversityORCID 0000-0002-8252-2595Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 7 Approach:experimental assay· 6 Research Focus:differential expression· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Paul GreengardiD· 4 shared Ana MiloseviciD· 2 shared Estefania P. AzevedoiD· 2 shared José Henrique LedoiD· 2 shared Kathryn A. McCabeiD· 2 shared Pedro Del Cioppo VasquesiD· 2 shared Tatiana FerraroiD· 2 shared Wei WangiD· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersNeuroscience

Paul GreengardORCID

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Author profile →

7 papers

Recent·Most cited

Astrocyte-derived extracellular matrix proteins regulate synapse remodeling in stress-induced depression

Ran Zhang, Patricia Rodriguez‐Rodriguez, Lucian Medrihan, Jerry C. Chang, Tatiana Ferraro, Pedro Del Cioppo Vasques, Wei Wang, Caroline Ménard, Flurin Cathomas, Kenny L. Chan, Lyonna F. Parise, Shai Shaham, Jean-Pierre Roussarie, Olga G. Troyanskaya, Scott J. Russo, Ana Milosevic

This study identifies astrocyte-derived extracellular matrix proteins, particularly SPARC, as regulators of synapse remodeling in stress-induced depression.

bioRxiv · Dec 30, 2024 · PreprintNeuroscience

Molecular and cellular adaptations in hippocampal parvalbumin neurons mediate behavioral responses to chronic social stress

Dionnet L. Bhatti, Lucian Medrihan, Michelle X. Chen, Junghee Jin, Kathryn A. McCabe, Wei Wang, Estefania P. Azevedo, José Henrique Ledo, Yong Deok Kim

Frontiers in Molecular Neuroscience · Jun 24, 2022Peer-reviewedNeuroscience

Glutamatergic projections from ventral hippocampus to nucleus accumbens cholinergic neurons are altered in a mouse model of depression

Lucian Medrihan, Margarete Grace Knudsen, Tatiana Ferraro, Pedro Del Cioppo Vasques, Yevgeniy Romin, Sho Fujisawa, Paul Greengard, Ana Milosevic

bioRxiv · Apr 20, 2022 · PreprintNeuroscience

HCN2 in cholinergic interneurons of the nucleus accumbens mediates reward response

J Lee, Marina Weinberger, Yuki Kawahara, J Cheng, Gall Umschweif, Lucian Medrihan, Marc Flajolet, Akinori Nishi, Yotam Sagi

This study shows that HCN2 in cholinergic interneurons of the nucleus accumbens enhances dopamine signaling in response to rewarding stimuli.

bioRxiv · Sep 21, 2021 · PreprintNeuroscience

A Developmental Role for Microglial Presenilin 1 in Memory

José Henrique Ledo, Estefania P. Azevedo, Lucian Medrihan, Jia Cheng, Hernandez Moura Silva, Kathryn A. McCabe, Michael A. Bamkole, Juan J. Lafaille, Jeffrey M. Friedman, Beth Stevens, Paul Greengard

This study shows that deleting Presenilin 1 in microglia during development enhances memory and neuronal activity in mice, with effects dependent on GluN2B and mitigating Alzheimer's symptoms.

bioRxiv · Jan 26, 2021 · PreprintNeuroscience

Reduced Kv3.1 Activity in Dentate Gyrus Parvalbumin Cells Induces Vulnerability to Depression.

Lucian Medrihan, Gali Umschweif, Anjana Sinha, Shayna Reed, Jinah Lee, Katherina Gindinova, Subhash C. Sinha, Paul Greengard, Yotam Sagi

Biological Psychiatry · Mar 4, 2020Peer-reviewedNeuroscience

Serotonin receptor 4 in mature excitatory hippocampal neurons modulates mood and anxiety

Remzi Karayol, Lucian Medrihan, Jennifer L. Warner‐Schmidt, Meghana N. Rao, Eva B. Holzner, Paul Greengard, Nathaniel Heintz, Eric F. Schmidt

This study shows that knocking out 5-HT4R in mature hippocampal excitatory neurons leads to anxiety-like behaviors and neural dysfunction.

bioRxiv · Sep 4, 2019 · PreprintNeuroscience