Author

Lucy Sinke

Leiden University Medical CenterORCID 0000-0002-9209-1266Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Genomics· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Assay:DNA methylation· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Bastiaan T. HeijmansiD· 4 shared Erik W. van ZwetiD· 2 shared Hailiang MeiiD· 2 shared Lucia DaxingeriD· 2 shared Yunfeng LiuiD· 2 shared Andreea Ioan‐FacsinayiD· 1 shared Bart EvertsiD· 1 shared Colette ChristianseniD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersGenetics

Bastiaan T. HeijmansORCID

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4 papers

Recent·Most cited

GeneticsMolecular PsychiatryPeer-reviewedOct 2, 2025

Identification of SENP7 and UTF1/VENTX as new loci influencing clusteredprotocadherin methylation across blood and brain using a genome-wide associationstudy

Yunfeng Liu, Maja Vukić, Eilis J. Hannon…·Bastiaan T. Heijmans

The paper identifies SENP7 and UTF1/VENTX as new loci influencing cPCDH methylation in blood and brain through a genome-wide association study.

1 citation

humanDNA methylation

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GenomicsbioRxivPreprintNov 29, 2024

DNA methylation and gene expression trajectories of human postprandial metabolism

Ricardo Costeira, Lidia Daimiel, Thies Gehrmann…·Jordana T. Bell

The paper identifies DNA methylation and gene expression changes in human blood after a meal, linking them to cardiometabolic health and obesity-related genes.

DOI 10.1101/2024.11.29.626085

humanDNA methylation

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GenomicsbioRxivPreprintFeb 16, 2024

Oleic acid triggers CD4+ T cells to be metabolically rewired and poised to differentiate into proinflammatory T cell subsets upon activation

Nathalie A. Reilly, Friederike Sonnet, Koen F. Dekkers…·Bastiaan T. Heijmans

This study shows that oleic acid pre-exposure rewires CD4+ T cell metabolism, promoting pro-inflammatory differentiation upon activation.

1 citation

humanbulk RNA-seq

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GeneticsClinical EpigeneticsPeer-reviewedAug 25, 2023

The inactive X chromosome accumulates widespread epigenetic variability with age

Yunfeng Liu, Lucy Sinke, Thomas H. Jonkman…·Bastiaan T. Heijmans

The paper identifies age-related increases in DNA methylation variability on the inactive X chromosome in females and males, with aVMCs accumulating in XCI regions and showing replication in purified cell types.

22 citations

humanDNA methylation

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