Carlos Matute

This study shows that marathon running causes reversible myelin reduction but preserves core brain function and cognitive abilities within a month.

This study shows that oligodendrocytes internalize exogenous myelin, enhancing their proliferation and differentiation through transcriptional changes and lipid droplet formation.

This study enhances mRNA translation efficiency by engineering Kozak repeats in the 5'-UTR, showing improved expression in both cell culture and mice.

This study shows GABAB receptors have dual roles in oligodendrocyte function and immune modulation in experimental MS, with baclofen showing therapeutic potential in reducing disease severity and promoting remyelination.

The paper identifies Thbs4-positive astrocytes from the SVZ that modulate the extracellular matrix at the glial scar after brain ischemia by synthesizing and degrading hyaluronan.

This study shows that astrocyte CB1R signaling promotes inflammation in MS by disrupting the blood-brain barrier and reducing BBB function.

This study identifies varicose projection astrocytes as a reactive phenotype associated with neuropathology, showing their presence in humans, mice, and tigers and their induction by inflammation.

This study shows that MCT2 is essential for oligodendrocyte myelin maintenance and axonal support, and its loss leads to myelin and axonal damage, which can be mitigated by a ketogenic diet.

This paper develops a mouse model of anti-NMDAR encephalitis to study neuro-immunology and assess treatment approaches, finding that anti-CD20 and NMDAR-PAM treatments reverse disease symptoms and neurobiological alterations.

The paper shows that an optimal ER-mitochondria distance of ~20 nm is critical for efficient Ca2+ transfer and mitochondrial oxidative metabolism, with reduced distances observed in Parkinson's disease astrocytes.

This study identifies TAF1-dependent transcriptional dysregulation as a mechanism underlying multiple sclerosis progression and presents an in vivo model for therapeutic development.

This study identifies aberrant astrocytic calcium signaling in MS models as a contributor to synaptic plasticity impairment and gray matter pathology.

This study shows that amyloid-beta oligomers disrupt RNA dynamics in oligodendrocytes by altering hnRNP A2 interactions, leading to increased translation of myelin proteins MBP and MOBP.

The paper shows that sub-clinical doses of NMDA and AMPA glutamate receptor antagonists protect against demyelination in experimental models of multiple sclerosis.

The paper defines lipid profiles for five brain cell types and maps their spatial distribution using mass spectrometry imaging.

This study shows marathon running causes widespread myelin reduction in the brain, which partially recovers within two weeks.

This study uses biophysical modeling to explore how nonlinear molecular interactions contribute to neuronal hyperactivity in early Alzheimer's disease, revealing diverse mechanisms that may explain different AD manifestations.

This study shows that IRF5 regulates microglial myelin clearance and cholesterol metabolism after demyelination, with implications for remyelination in multiple sclerosis.

The paper reveals column- and layer-specific astrocyte-mediated non-synaptic communication between cortical neurons through CB1R activation and ATP/adenosine release.

This study shows that genetically-modified macrophages can deliver Sema3F to demyelinating lesions, increasing OPC recruitment and accelerating remyelination in mice.

The paper shows that depleting microglia and meningeal macrophages delays the onset of EAE by reducing antigen presentation and T cell reactivation.

This study shows clemastine increases oligodendrocyte differentiation but impairs myelination during development, likely due to microglia-oligodendrocyte interactions.

This study shows baclofen, a GABABR agonist, promotes remyelination in mouse models of demyelination, suggesting it could be a therapeutic for multiple sclerosis.

The paper develops a triple co-culture model of neurons, microglia, and astrocytes to study Alzheimer's disease, showing reduced inflammation and synaptic loss in response to Aβ.