imputation

Evaluation of the accuracy of imputed sequence variants and their utility for causal variant detection in cattle

This study evaluates imputation accuracy in cattle and identifies QTL for milk fat percentage using imputed variants.

Resolving Biology Beyond the Diffraction Limit with Single-Molecule Localization Microscopy

This paper reviews single-molecule localization microscopy and its potential for advancing biological imaging beyond diffraction limits.

Bright photoactivatable fluorophores for single-molecule imaging

The paper introduces photoactivatable derivatives of Janelia Fluor dyes for enhanced single-molecule imaging in live cells.

A reference panel of 64,976 haplotypes for genotype imputation

The paper constructs a haplotype reference panel for genotype imputation, enabling accurate imputation at low minor allele frequencies and enhancing association studies.

Reference-based phasing using the Haplotype Reference Consortium panel

This paper introduces Eagle2, a reference-based phasing algorithm that improves accuracy and speed compared to SHAPEIT2 using the Haplotype Reference Consortium panel.

Anisotropic Correction of Beam-induced Motion for Improved Single-particle Electron Cryo-microscopy

The paper develops an algorithm to correct anisotropic beam-induced motion in cryo-electron microscopy, improving resolution and reconstruction quality.

A high-quality reference panel reveals the complexity and distribution of structural genome changes in a human population

This study creates a high-quality reference panel of structural variants from 769 Dutch individuals, revealing new variants and their linkage to known SNPs, improving imputation accuracy for genome-wide association studies.

Choosing panels of genomics assays using submodular optimization

This paper introduces SSA, a method for selecting optimal genomic assays using submodular optimization, and demonstrates its effectiveness on epigenomic data.

Whole-genome characterization in pedigreed non-human primates using Genotyping-By-Sequencing and imputation.

The paper develops a cost-effective method to impute whole-genome sequence data in pedigreed non-human primates using Genotyping-By-Sequencing and the GIGI algorithm, achieving high accuracy with fewer sequenced individuals.

Fast and accurate long-range phasing in a UK Biobank cohort

This paper introduces Eagle, a fast and accurate long-range phasing method applied to the UK Biobank cohort, achieving high accuracy and speed for rare variant imputation.

Choosing subsamples for sequencing studies by minimizing the average distance to the closest leaf

The paper introduces a method to select internal reference panels for imputation by minimizing average distance to the closest leaf, showing improved accuracy compared to maximizing phylogenetic diversity.

Two-Dimensional Mapping of 3D Data from Confocal Microscopy

This paper introduces a method to convert 3D confocal microscopy data into 2D visualizations while preserving size and shape consistency.

Ultra fast tissue staining with chemical tags

This paper introduces a chemical tagging method for rapid, low-background labeling of thick tissues, demonstrating 100x faster staining of whole-mount fly brains.