Schizophrenia research and treatment

This study analyzes schizophrenia GWAS data to identify drug targets and pathways, finding significant enrichment for known antipsychotics and novel therapeutic opportunities.

The paper reports GWAS findings linking common variants in NRXN1, LRP1B, and RORA to increased ventricular volumes in psychosis, using deep phenotyping data from 1,115 cases and controls.

The paper confirms a polygenic effect on negative symptoms in schizophrenia using GWAS, identifies novel loci, and highlights the need for larger samples.

The paper identifies cerebral ischemia-induced genes as significantly overexpressed in the frontal cortex of acute schizophrenia patients, supporting the ischemia hypothesis for schizophrenia.

The paper rescues network dynamics and behaviour in a mouse model of schizophrenia by restoring parvalbumin interneuron excitability.

The paper evaluates chromatin accessibility in prefrontal cortex samples from schizophrenia cases and controls, finding high heritability enrichment in open chromatin regions but no differential accessibility between groups.

This paper investigates how global polygenic risk scores, sex, and their interaction predict schizophrenia risk using a classification model, finding sex and polygenic risk are the strongest predictors.

The paper investigates the association between schizophrenia genetic risk and cognitive performance in healthy individuals, finding a link with current cognitive abilities but not with premorbid intelligence or education.

The paper investigates how loneliness and desire for social connectedness relate to emotional prosody perception in schizophrenia, finding reduced prosody acuity and correlations between NTB and prosody perception.

The paper confirms lower brain pH in schizophrenia and bipolar disorder patients and shows it persists in animal models, suggesting it is a pathophysiological feature rather than an artifact.