Schizophrenia research and treatment

Aberrant cerebrovascular reactivity presents as an early biomarker of psychosis susceptibility in patients with 22q11.2DS

This study identifies early cerebrovascular reactivity impairments in 22q11.2DS as a biomarker for psychosis susceptibility, particularly in regions like the anterior cingulate cortex and globi pallidi.

Subtyping psychotic disorders using a data-driven approach reveals divergent cortical and cellular signatures

This study identifies two subtypes of psychosis using SNF, showing distinct cortical and cellular signatures linked to different clinical and neuroanatomical features.

Disrupted Emotional Neural Synchrony in Schizophrenia Revealed by Intersubject Correlation of Naturalistic fMRI

This study uses intersubject correlation of naturalistic fMRI data to show reduced emotional neural synchrony in schizophrenia, particularly in the amygdala, and increased synchrony in visual and frontal regions.

Disruption of Reelin signaling in a dual-hit mouse model of schizophrenia: impact of postnatal Δ9-tetrahydrocannabinol exposure in a maternal immune activation model

This paper develops a dual-hit mouse model of schizophrenia combining maternal immune activation and postnatal THC exposure, finding reduced Reelin levels and altered brain structure in treated mice.

Reduced synaptic plasticity and E/I imbalance drive Peripersonal Space boundaries expansion in Schizophrenia

The paper develops a computational model of peripersonal space (PPS) plasticity in schizophrenia, finding that reduced synaptic plasticity mechanisms can explain PPS expansion despite E/I imbalance.

Multiplex Portuguese Families as a Lens into rare mutations and the Shared Genetic Architecture of Schizophrenia, Mood Disorders, and Autism Spectrum Disorders

This study analyzes 173 multiplex Portuguese families to identify rare genetic variants associated with schizophrenia, mood disorders, and autism, finding a CHD2 mutation linked to diverse mental illness phenotypes.

Linking reduced prefrontal microcircuit inhibition in schizophrenia to EEG biomarkers in silico

This study links reduced PV and SST interneuron inhibition in schizophrenia to distinct EEG biomarkers using in silico simulations of prefrontal microcircuits.

Schizophrenia, variability, and the Anna Karenina principle

The paper shows that higher variance in schizophrenia patients arises from greater perturbation counts, not disease-specific factors, highlighting the need to address broad damaging factors rather than specific pathologies.

Schizophrenia risk gene ZNF804A controls ribosome localization and synaptogenesis in developing human neurons

This study investigates the role of ZNF804A in human neurodevelopment, finding it regulates excitatory synapse formation through increased local protein translation in developing cortical glutamatergic neurons.

Rare coding variants in schizophrenia-associated genes affect generalised cognition in the UK Biobank

The paper investigates the effect of rare coding variants in schizophrenia-associated genes on generalised cognition in the UK Biobank using exome-sequencing data.

Antipsychotic-like effects of the selective Rho-kinase 2 inhibitor KD025 in genetic and pharmacological mouse models of schizophrenia

This study shows that the selective ROCK2 inhibitor KD025 has antipsychotic-like effects and fewer side effects in schizophrenia models.

In vivo mapping of protein-protein interactions of schizophrenia risk factors generates an interconnected disease network.

The paper maps protein-protein interactions of schizophrenia risk factors in rodent brains, revealing an interconnected disease network and showing how PCP perturbations alter these interactions.

Dissociable Anterior and Posterior Beta-Burst Dynamics Track Thought Disorder in Schizophrenia

This study examines beta-burst dynamics in schizophrenia patients and controls, finding dissociable anterior and posterior abnormalities linked to speech markers of thought disorder.

Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder

This study investigates Akap11 mutant mice to explore the neurobiological effects of AKAP11 loss, finding increased PKA activity and transcriptomic changes linked to schizophrenia and bipolar disorder.

Cortical excitatory and inhibitory neuron deficits may underlie the cognitive and social impairments in a mouse model of schizophrenia with exonic Reln deletion

This paper investigates the role of Reelin in schizophrenia by analyzing a mouse model with exonic Reln deletion, finding deficits in excitatory and inhibitory neurons and suggesting therapeutic potential for Reelin replacement.

The Dynamic Nature of Genetic Risk for Schizophrenia Within Genes Regulated by FOXP1 During Neurodevelopment

This study identifies FOXP1-regulated genes across developmental stages and shows their enrichment for schizophrenia heritability, particularly in early childhood and adolescence.

Transcriptomic analysis of the human habenula in schizophrenia

The paper performs transcriptomic analysis of the human habenula and identifies molecular changes associated with schizophrenia risk and illness state.

Linking Brain Entropy to Molecular and Cellular Architecture in Psychosis

The paper links brain entropy to molecular and cellular architecture in psychosis by analyzing differences in neurotransmitter systems and mitochondrial markers between healthy controls and individuals with schizophrenia or bipolar disorder.

Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus

This study performs a meta-analysis of brain transcriptomes from genetic mouse models of schizophrenia, identifying dysregulation in striatum and thalamus with distinct patterns in different models.

Apomorphine susceptibility and prenatal infection alter neurodevelopment, synaptic density and anticipatory behavior in rats

This study examines how polygenic susceptibility and prenatal immune activation affect neurodevelopment, synaptic density, and behavior in apomorphine-susceptible rats.

PV+ optogenetic stimulations at specific frequencies in specific brain regions can restore navigational flexibility in an acute MK801 mouse model of schizophrenia

The paper investigates how frequency-specific optogenetic stimulation of PV+ interneurons in mPFC and vHPC can restore navigational flexibility in an acute MK801 mouse model of schizophrenia.

Neurodevelopmentally rooted epicenters in schizophrenia: sensorimotor-association spatial axis of cortical thickness alterations

This study identifies neurodevelopmentally rooted epicenters of cortical thickness alterations in schizophrenia, linking them to specific functional regions and genetic factors.

Blood and Neuronal Extracellular Vesicle Mitochondrial Disruptions in Schizophrenia

This study finds elevated mitochondrial DNA levels in blood and neuronal extracellular vesicles in schizophrenia patients, linked to brain lactate and developmental stress.

Real-time fMRI neurofeedback modulates auditory cortex activity and connectivity in schizophrenia patients with auditory hallucinations: A controlled study

Pharmacogenetic Study of Antipsychotic-Induced Lipid and BMI Changes in Chinese Schizophrenia Patients: A Genome-Wide Association Study

This study identifies genetic variants associated with antipsychotic-induced lipid and BMI changes in schizophrenia patients using GWAS, offering potential for personalized treatment strategies.

Cerebellar-Prefrontal Connectivity Predicts Negative Symptom Severity Across the Psychosis Spectrum

This study finds that higher cerebellar-prefrontal connectivity is associated with lower negative symptom severity and better cognitive performance in individuals with psychotic disorders.

Temporal characteristics of hemodynamic responses during active and passive hand movements in schizophrenia spectrum disorder

This study examines hemodynamic response timing differences during active and passive hand movements in schizophrenia spectrum disorder, finding delayed BOLD activation in SSD patients in specific brain regions.

Binomial order is a speech marker of psychosis and thought disorder

The paper examines binomial ordering preferences in speech as a potential marker for thought disorder in psychotic disorders, finding higher rates of atypical orderings in patients.

Restoring Synaptic Balance in Schizophrenia: Insights from a thalamo-cortical conductance-based model.

This study identifies synaptic disturbances in schizophrenia using magnetoencephalography and dynamic causal modeling, showing that targeted synaptic restoration can realign neural activity to healthy patterns.

GABA, Glutamate dynamics and BOLD observed during cognitive processing in psychosis patients with hallucinatory traits

The paper investigates GABA and Glutamate dynamics along with BOLD signals in psychosis patients with hallucinations during a cognitive task, finding baseline Glx differences and altered BOLD-Glx associations.