Integrative scRNA-seq and spatial transcriptomics uncovers distinct macrophage-fibroblast cross-talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritis
Gulzada Kulzhanova, Alexis Klee, Mina Botros, Victoria L. Hansen, John E. Reuter, Eliya Tazreena Tashbib, Eloise Fadial, Benjamin F. Ricciardi, Brian D. Giordano, Chia‐Lung Wu
In hip osteoarthritis (OA) versus femoroacetabular impingement (FAI) synovium, inflammatory EREG+ lining fibroblasts expand and co-localize more with COL1A1+ fibrotic macrophages; FGF2-SDC4 is their top predicted interaction.
Arthritis & Rheumatology · Jan 12, 2026Peer-reviewedPathology✦ In-depth digest