Chia‐Lung Wu

This study identifies PRDM16 loss as a driver of nasal septal deviation through TGFβ2 signaling dysregulation in mice.

This study identifies PRDM16 as a critical regulator of chondrogenesis and chondrocyte identity in the knee joint through DNA binding and histone modification.

In hip osteoarthritis (OA) versus femoroacetabular impingement (FAI) synovium, inflammatory EREG+ lining fibroblasts expand and co-localize more with COL1A1+ fibrotic macrophages; FGF2-SDC4 is their top predicted interaction.

This study shows that ADGRG6 is essential for postnatal growth plate homeostasis in mice, affecting chondrocyte survival, proliferation, and differentiation.

This study investigates how TRPV4 mutations affect chondrocyte differentiation and identifies altered BMP signaling as a mechanism for skeletal dysplasia.

The paper uses whole-genome RNA sequencing to compare cartilage transcriptomes of FAI and OA patients, identifying FGF18 as a potential biomarker for hip OA progression.

This paper develops a bioartificial implant using CRISPR-Cas9-engineered stem cells to deliver anti-cytokine drugs in response to inflammation, reducing arthritis severity in mice.

This study combines lineage tracing and spatial transcriptomics to define the activation profile and fate trajectory of adult Scleraxis-lineage cells during tendon healing, identifying key molecular regions and their roles in healing.