Victoria L. Hansen

Loss of PRDM16 Drives Nasal Septal Deviation through Dysregulated TGFβ2 Signaling

This study identifies PRDM16 loss as a driver of nasal septal deviation through TGFβ2 signaling dysregulation in mice.

PRDM16 Coordinates Genetic and Epigenetic Programs Governing Chondrogenesis and Chondrocyte Phenotype Specification in the Knee Joint

This study identifies PRDM16 as a critical regulator of chondrogenesis and chondrocyte identity in the knee joint through DNA binding and histone modification.

Integrative scRNA-seq and spatial transcriptomics uncovers distinct macrophage-fibroblast cross-talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritis

In hip osteoarthritis (OA) versus femoroacetabular impingement (FAI) synovium, inflammatory EREG+ lining fibroblasts expand and co-localize more with COL1A1+ fibrotic macrophages; FGF2-SDC4 is their top predicted interaction.

Spatial Transcriptomics Reveals the Requirement of ADGRG6 in Maintaining Chondrocyte Homeostasis in Mouse Growth Plates

This study shows that ADGRG6 is essential for postnatal growth plate homeostasis in mice, affecting chondrocyte survival, proliferation, and differentiation.

Whole-Genome RNA Sequencing of Femoral Head Impingement Cartilage Identifies FGF18 As A Biomarker in Hip Osteoarthritis Progression

The paper uses whole-genome RNA sequencing to compare cartilage transcriptomes of FAI and OA patients, identifying FGF18 as a potential biomarker for hip OA progression.