Author

Brian D. Giordano

University of Rochester MedicineORCID 0000-0002-2021-7587Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Approach:experimental assay· 1

Frequent Co-Authors

Chia‐Lung WuiD· 2 shared Victoria L. HanseniD· 2 shared Alexis Klee· 1 shared Benjamin D. KuhnsiD· 1 shared Benjamin F. RicciardiiD· 1 shared Cheryl L. Ackert‐BicknelliD· 1 shared Eliya Tazreena TashbibiD· 1 shared Eloise FadialiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersPathology

Chia‐Lung WuORCID

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2 papers

Recent·Most cited

PathologyArthritis & RheumatologyPeer-reviewedJan 12, 2026

✦ In-depth digest

Integrative scRNA-seq and spatial transcriptomics uncovers distinct macrophage-fibroblast cross-talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritis

Gulzada Kulzhanova, Alexis Klee, Mina Botros…·Chia‐Lung Wu

In hip osteoarthritis (OA) versus femoroacetabular impingement (FAI) synovium, inflammatory EREG+ lining fibroblasts expand and co-localize more with COL1A1+ fibrotic macrophages; FGF2-SDC4 is their top predicted interaction.

12 citationstop 1%

humanscRNA-seq

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BioinformaticsbioRxivPreprintMay 23, 2022

Whole-Genome RNA Sequencing of Femoral Head Impingement Cartilage Identifies FGF18 As A Biomarker in Hip Osteoarthritis Progression

Benjamin D. Kuhns, John M. Reuter, Victoria L. Hansen…·Brian D. Giordano

The paper uses whole-genome RNA sequencing to compare cartilage transcriptomes of FAI and OA patients, identifying FGF18 as a potential biomarker for hip OA progression.

DOI 10.1101/2022.05.23.492951

humanbulk RNA-seq

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