Osteoarthritis Treatment and Mechanisms

This study shows that inhibiting hexokinase 2 (HK2) impairs cartilage formation and accelerates osteoarthritis progression in mice.

This study examines how mechanical injury alters metabolism in bovine and human chondrocytes, revealing differences in oxygen consumption and glutamine accumulation between healthy and osteoarthritic cells.

This study shows that mismatch in cartilage thickness and mechanical properties at the patellar osteochondral allograft interface leads to localized high-strain regions that may cause graft failure.

This study investigates how cyclical compression and shear deformations affect central metabolites in chondrocytes, showing changes in metabolites that could inform therapeutic mechanotransduction for cartilage repair.

This study develops a stoichiometric model of chondrocyte metabolism to examine how cyclical shear and compressive loading affect matrix protein synthesis, revealing sex-dependent differences and nitrogen limitations.

This study characterizes gene expression in human growth plates, identifying novel markers and sub-populations of resting zone chondrocytes with features of quiescent stem cells.

This study investigates how Wnt signaling and α5β1 integrins interact to modulate mechanical responses in human cartilage, showing integrins mediate Wnt-driven changes in load responsiveness.

This study examines age-related changes in mineralized cartilage and subchondral bone in rat tibiae, revealing structural and material alterations linked to joint degeneration.

This study investigates the acute effects of intra-articular IDO-1 liposomes after ACL injury, showing reduced tryptophan, inflammation markers, and altered T cell ratios, with increased cartilage thickness in rats.

This study shows that dynasore, a dynamin inhibitor, has hormetic effects on bone growth, stimulating elongation at low doses and inhibiting growth at high doses.

The paper identifies LAMA5 as a candidate gene for idiopathic short stature, showing its role in ECM-WNT signaling during chondrogenesis and demonstrating partial rescue via WNT activation.

This study identifies KIT and CSF1R as key genes in osteoarthritis using transcriptome data and validates their expression in clinical samples.

This study uses a mouse model to investigate how acute synovitis and mechanical stress contribute to PTOA, identifying miRNA signatures in synovial fluid that may protect against cartilage degeneration.

This study shows decorin strengthens collagen II-aggrecan integration in cartilage matrix, reducing aggrecan loss and supporting its therapeutic potential for osteoarthritis.

This study evaluates iopanoic acid's therapeutic effects on osteoarthritis using mouse models and human tissue explants, showing reduced cartilage degradation and improved repair.

This study compares bioreactor loading protocols to finite element models of the human knee to assess their ability to replicate native joint mechanics.

This paper develops a multiscale model linking tissue mechanics, cellular forces, and gene regulation in articular cartilage to study OA pathophysiology.

This study shows that proteoglycan loss is less severe in the pericellular matrix than in the extracellular matrix in the middle zone of cartilage early after ACLT in rabbits.

This study reveals GH directly stimulates human growth plate stem cell proliferation via TGF{beta} and ERK pathways, offering insights into growth mechanisms and treatment optimization.

This study shows that repeated NGF injections into mouse knees cause multiple OA-like features without cartilage damage.

This study proposes a biomechanical mechanism for collagen architecture in articular cartilage, showing how fluid flow from joint movements guides fiber alignment and adapts to activity and disease.

The paper investigates how moderate exercise in early OA rats upregulates CILP in the cartilage intermediate zone, inhibiting fibrosis and ferroptosis via the Keap1-Nrf2 axis.

This study identifies the LEP-LEPR-CD31 signaling pathway's role in subchondral H-type vessel formation and its contribution to articular cartilage degeneration in osteoarthritis.

This study identifies sex-specific metabolic changes in injured joints of male and female mice using MALDI-MSI and metabolomics, revealing tissue-specific and spatially dependent metabolic signatures.

The study shows CD14 is critical for pain and inflammation in post-traumatic osteoarthritis and that blocking CD14 can reduce pain and mobility loss.

This study identifies miR-544a as a modulator of Wnt signaling in OA chondrocytes, showing it enhances Wnt activation and promotes catabolism.

This study uses hPSCs to model MED with MATN3 mutations, revealing altered matrix organisation and upregulated cholesterol biosynthesis pathway.

This study uses spatial mass spectrometry imaging to identify ECM peptide markers distinguishing OA-affected subchondral bone from healthy tissue and less affected regions.

This study investigates the roles of JMJD3 and UTX in chondrogenesis using mesenchymal stem cells and finds JMJD3 is critical for cartilage formation while UTX is dispensable.

This study develops a computational model to simulate collagen loss in cartilage after injury, showing that MMP release from damaged cells leads to significant collagen degradation.