Autism Spectrum Disorder Research

AI-driven framework modeling perturbation in brain organoids reveals candidate genes for autism

The paper uses an AI-driven framework to model perturbations in brain organoids and identifies candidate genes for autism using genomic and clinical data.

Rare variation illuminates the distinct and pleiotropic genetic architecture of autism across neuropsychiatric traits

The paper identifies 253 autism-associated genes using rare variation from 62,429 individuals and finds pleiotropy across physiological systems and developmental disorders.

TMAO miscompartmentalization is a reversible driver of autism pathophysiology

This study identifies TMAO miscompartmentalization as a reversible factor in ASD pathophysiology, showing urea can restore biochemical and behavioral abnormalities in a rat model.

Sex specificity of inhibitory gating deficits in individuals with high autistic traits

This study investigates sex-specific inhibitory gating deficits in individuals with high autistic traits, finding that the deficit is stimulus-dependent and specific to non-social stimuli.

Sub-Additive Effects of Autism-ADHD Comorbidity on Resting-State Pupillary and Oculomotor Phenotypes

The paper examines how autism and ADHD comorbidity affects resting-state pupillary and oculomotor traits using dimensional and categorical frameworks in a large pediatric cohort.

Structural brain alterations in autism: A voxel-based morphometry mega-analysis in 3,051 participants across 51 sites

This paper identifies widespread gray and white matter volume differences in autism using a large voxel-based morphometry analysis of 3,051 participants.

Visual Cortical Response Variability in Infants at High Familial Likelihood for Autism

Among infant siblings of autistic children, greater trial-to-trial variability in visual P1 latency at 6 and 12 months tracked higher 24-month cognitive and language scores; mean P1 measures did not.

Distinct transcriptomic and hierarchical organization associated with brain hyperconnectivity and hypoconnectivity in autism spectrum disorder

The paper identifies distinct transcriptomic and hierarchical brain organization associated with hyperconnectivity and hypoconnectivity in autism spectrum disorder, showing they are separate phenomena rather than opposing aspects of a single process.

Specific, replicable behavioral and neural correlates of sensory over-responsivity in childhood

This study identifies consistent clinical and neural correlates of sensory over-responsivity (SOR) across diverse child samples, showing associations with autistic traits, anxiety, and specific brain connectivity patterns.

Genomic, Transcriptomic, and Regulomic Analyses Do Not Support Profound Autism as a Distinct Biological Category

The paper analyzes genomic, transcriptomic, and regulomic data to assess if 'profound autism' is a distinct biological category, finding no evidence for such a category.

The Q1K Integrated EEG and Eye-Tracking Experimental Test Battery for Open Autism Science

An open, instruction-free EEG plus eye-tracking task battery for autism families (344 to 587 participants per task so far), with timing-validated integrated recordings that enable gaze-locked ERP analysis.

Altered Stress and Fear Responses in the VPA Rat Model of Autism: Behavioral Dissociation Across Tactile, Nociceptive, and Social Contexts

This study examines stress and fear responses in VPA-treated rats, finding heightened reactivity and disrupted coordination of fear responses compared to controls.

Autistic and non-autistic adults similarly experience statistical regularities

The paper examines how autistic and non-autistic adults experience statistical regularities and finds similar subjective probability and surprise ratings, with comparable effects on perceptual decisions.

Neurophysiological Evidence for Reduced Use of Prior Sound Patterns to Shape Speech Processing in Autism

This study finds that autistic adults show reduced context-dependent modulation of speech encoding compared to non-autistic adults, linked to differences in auditory and social-communicative function.

Autistic traits modulate neural responses to social signals during natural vision

The paper examines how autistic traits affect neural responses to social signals in naturalistic stimuli using fMRI and finds consistent effects in the superior temporal gyrus across two experiments.

Processing of Emotional Faces Has Unique Functional and Cytoarchitectural Associations in those with an Autism Spectrum Diagnosis.

The study investigates the relationship between neuron density and functional activity in the amygdala during emotional face processing in individuals with ASD compared to neurotypical controls.

A Novel Phenotype-based Approach for Prioritizing Candidate Genetic Variants for Autism Spectrum Disorder.

This paper introduces a phenotype-based method to prioritize genetic variants in ASD, improving diagnostic yield and identifying novel variants in unresolved cases.

Altered aperiodic EEG spectral power during speech perception task is associated with verbal communication in youths with Autism Spectrum Disorder

The paper investigates altered aperiodic EEG spectral power during speech perception in youths with ASD, linking increased neural noise to lower verbal communication skills.

Altered biological aging-related brain profile in adolescents with autism: A neuroimaging study based on DunedinPACNI

This study finds that adolescents with autism have higher biological aging rates in brain structures compared to neurotypical controls, as measured by DunedinPACNI.

A survey-based study investigating opinions on genetic research among Swedish autistic individuals and parents of autistic children

This study surveys Swedish autistic individuals and parents to assess their attitudes toward genetic research, finding generally positive views with concerns about misuse and eugenics.

Genes/variants for diagnostic testing and pre-clinical research in autism spectrum disorder

The paper curates 222 genes associated with autism spectrum disorder (ASD) using the EAGLE framework, identifying 78 with definitive evidence and highlighting differential expression patterns between ASD and broader neurodevelopmental disorders.

Reward network state dynamics track ASD symptom severity but not diagnosis

This study examines reward network dynamics in ASD using fMRI, finding that temporal activity patterns correlate with symptom severity but not diagnosis.

Disruption of Myelin-Associated Glycoprotein Activity Drives Aberrant Cerebellar Neurodevelopment and Autism-Like Behaviors.

This study shows that disrupting MAG activity during early postnatal life alters cerebellar development and induces autism-like behaviors through immune-mediated mechanisms.

Cortical Excitation-Inhibition Balance in Autism Varies by Brain Region and Age

The paper examines developmental changes in cortical excitation-inhibition balance in ASD across brain regions and age, finding regionally and developmentally specific differences.

Decoding the Genetic Architecture of Autistic Traits in the Aging Population

The paper identifies genetic variants associated with autistic traits in adults aged 40 and above using UK Biobank and SPARK cohorts, linking them to brain structure and function.

Altered cognitive processes shape tactile perception in autism.

This study shows that cognitive processes affect tactile perception in autism using a mouse model, revealing context-dependent sensory processing changes.

Preserved self-other integration during social decision making among individuals with elevated autistic traits

This study investigates whether autistic traits affect self-bias and social basis function use during social decision-making, finding no significant relationship.

Parental educational attainment polygenic scores contribute to phenotypic heterogeneity in offspring with autism

This study shows parental educational attainment polygenic scores influence offspring autism symptoms through indirect genetic effects and are linked to later diagnosis age.

Asymmetric neural dynamics of visuospatial attention in autism spectrum disorder

This study examines neural dynamics of visuospatial attention in ASD and TD individuals, finding similar leftward attention mechanisms but distinct rightward dynamics in ASD.

Fetal MRI reveals altered prenatal cortical surface area in fetuses later diagnosed with autism spectrum disorder

The paper uses fetal MRI to find reduced cortical surface area in fetuses later diagnosed with ASD compared to controls.