Autism Spectrum Disorder Research

Sex and autism share cell type-specific effects on cortical gene expression

The paper examines cell type-specific sex effects on gene expression in autism and finds a stronger overlap with autism than schizophrenia.

Heightened gaze responsiveness and mutual gaze instability at close distances characterize dyadic coordination in a marmoset model of autism

This study examines dyadic coordination in a marmoset model of autism, finding heightened gaze responsiveness and unstable mutual gaze at close distances in affected pairs.

Comparing the Phenotypic and Genetic Differences Between Autistic Regression and Autism Without Regression Using the SPARK Cohort

The paper compares phenotypic and genetic differences between autistic regression and autism without regression using the SPARK cohort, finding increased neurodevelopmental morbidity and minimal genetic explanation.

Neurocognitive characteristics of perceptual feedback processing differ in autism

The paper investigates neurocognitive differences in perceptual feedback processing between autistic and non-autistic adults, finding reduced feedback-related negativity and weaker modulation by perceptual difficulty in autistic individuals.

Rationalizing sensorimotor deficits in autism spectrum disorder

This study uses a virtual reality task and Inverse Rational Control to identify sensory and motor differences in ASD compared to neurotypical individuals.

Phenotypic structure and genetic correlates of adolescent psychiatric symptomatology in versus out of autism

The paper compares the phenotypic and genetic structures of psychiatric symptoms in autistic and non-autistic children, finding differences in factor structures and genetic associations.

Tonotopic mapping in children shows an overrepresentation of high frequencies in autism

The paper examines tonotopic mapping in children with autism and finds an overrepresentation of high frequencies in their auditory cortex, suggesting early disruption in tonotopic map formation.

Synaptic density imaging associates with performance but not self-report in autism

The paper examines the relationship between synaptic density imaging and performance versus self-report measures in autism, finding a dissociation where synaptic density correlates with performance but not self-report.

Retinal cell mosaics in the valproate-induced rat model of autism spectrum disorder

The paper examines changes in retinal neuron density and spatial organization in a rat model of autism spectrum disorder induced by prenatal valproate exposure.

The superior temporal asymmetrical pit remains asymmetric in autism spectrum disorder

The paper examines STAP and STS subregions in ASD and NT individuals, finding no group differences but linking pSTS laterality to social cognition.

Multimodal MRI Clustering Reveals an Elevated Free-Water Biotype in Autism with Increased Social Symptoms

The paper identifies a subgroup of individuals with autism characterized by elevated free-water levels and social difficulties using multimodal MRI clustering.

Task-based functional connectivity in striato-motor-cortical system in autism: Associations with sex and executive function

The paper examines functional connectivity between striatal and frontal brain regions in autistic females, finding reduced connectivity and its association with executive function.

Xenon improves autism-like behaviors in mice through potentiation of PVT-CeA glutamatergic neurotransmission

Xenon improves ASD-like behaviors in mice by enhancing PVT-CeA glutamatergic neurotransmission through reduced GABAergic inhibition.

Autism genes converge on three functional programs organized by neuronal subclass, developmental timing, and cortical patterning

This study identifies three functional programs impacted by autism genes, contextualized across neuronal subclasses, developmental timing, and cortical regions.

Environmental Enrichment Remodels Brain Structural and Behavioral Plasticity in Restricted and Repetitive C58 Mouse Models

This study shows environmental enrichment reduces restricted behaviors in C58 mice by altering brain structure and microstructure, with strain and sex-dependent effects.

Sensory and developmental phenotyping of C. elegans parses autism associated genes into behavioural classifications

This study uses C. elegans to investigate epigenetic modifiers linked to autism spectrum disorder, identifying behavioral and phenotypic changes related to sensory processing and development.

Cntnap2 deletion in mice causes developmentally transient alterations in auditory processing and persistent startle hyperreactivity

This study shows that Cntnap2 deletion in mice causes transient auditory brainstem changes and persistent startle hyperreactivity in males, similar to rats but with sex-specific effects.

System-Specific Epigenetic Aging Signatures in Autistic Adults

Saliva methylation from 37 autistic adults vs 188 public controls showed elevated Brain, Blood and Liver SystemsAge subscores, while global clocks (Horvath, GrimAge, DunedinPACE) showed no difference.

Cell-type-resolved DNA methylation profiling in the cortex reveals female-specific X chromosome differences in autism

The paper identifies cell-type-specific DNA methylation differences in autism, revealing female-specific X chromosome alterations in microglia.

Feasibility of multimodal behavioral, gaze, and EEG measurement of natural scene segmentation in autism

This paper presents a multimodal framework combining EEG, eye-tracking, and behavioral responses to study natural scene segmentation in ASD and NT individuals, revealing cohort differences in perception and attention.

A reproducible buccal transcriptomic response to music exposure in autism spectrum disorder: insights into the oral-brain axis

The paper identifies a reproducible transcriptional response to music exposure in ASD using buccal samples, highlighting neuroimmune pathways and a two-gene signature for monitoring interventions.

Autistic Traits are Associated with Suboptimal Decision Bias Strategies in Subsecond Timing

This study finds that autistic traits are linked to a suboptimal decision bias strategy in subsecond timing tasks, not reduced perceptual sensitivity.

Characterizing Features of the Genetic Architecture Underlying Autism from a Multi-Ancestry Perspective

The paper identifies ancestry-specific genetic loci associated with autism spectrum disorder using admixture mapping across diverse populations.

Reduced EEG Complexity and Its Association with Social Communication in Adults with Autism Spectrum Disorder: A Multiscale Entropy Study

This study examines reduced multiscale entropy (MSE) in adults with autism spectrum disorder (ASD) and its association with social communication, using EEG data during rest and movie viewing conditions.

Developmental Dynamics of Phenotypic Architecture in ASD

This study identifies a reproducible sensory-repetitive-centered phenotypic architecture in ASD across multiple cohorts and shows developmental changes in its organization.

Sexual dimorphism of autism-like phenotypes in microglial eIF4E overexpression mice

This study shows that sex hormones, not sex chromosomes, drive male-biased ASD-like phenotypes in microglial eIF4E overexpression mice.

Systematic CRISPRi perturbation of 1,408 autism risk genes maps multilevel transcriptional convergence in human cortical neurons

This study uses CRISPRi Perturb-seq to analyze 1,408 autism risk genes in human cortical neurons, identifying 215 genes that cause global transcriptomic dysregulation and uncovering shared transcriptional pathways.

Effects of polygenic liability for autism on neonatal thalamocortical connectivity and behavioral outcomes across sex

The paper examines how polygenic liability for autism affects neonatal thalamocortical connectivity and behavioral outcomes, revealing sex-specific impacts on brain connectivity and motor development.

Neonatal Muscle Tone Predicts Cerebellar Morphology Later in Development Without Mediating Autistic Traits

The paper examines the relationship between infant muscle tone and cerebellar morphology in adolescence, finding specific cerebellar volume associations but no mediation of autistic traits.

Estimating the contribution of coding mutations to autism

The paper estimates the contribution of de novo coding mutations to autism using data from 38,680 trios, finding they explain 3.4% of autism variance.