Antibiotic Resistance in Bacteria

The paper integrates whole-genome sequencing into the Philippines' antimicrobial resistance surveillance program to better understand and track carbapenem resistance in key bacterial species.

This study sequenced 176 Pseudomonas aeruginosa isolates from the Philippines to characterize their genomic diversity, antimicrobial resistance mechanisms, and clonal spread.

This study maps major bacterial antibiotic resistance genes in Australian fecal samples using shotgun metagenomics and targeted sequencing, finding higher ARG abundance in human and dog samples than in ducks.

The paper investigates the phylogenetic relationships and global distribution of blaKPC-2 and blaNDM-1 genes in carbapenem-resistant Klebsiella pneumoniae using NGS data.

The paper develops a metagenomic metric to predict antibiotic resistance in Enterobacterales infections using pooled human faecal samples from LMICs and high-income settings.

This paper analyzes antimicrobial resistance assay data to identify biases and contradictions in training data for machine learning models.

The paper analyzes metagenomic time-series data to track the spread of antibiotic resistance genes through bacterial chromosomes, plasmids, and phages during antibiotic therapy.

This study analyzes the genomic epidemiology of a blaKPC carbapenemase outbreak in Enterobacterales in the UK, revealing genetic plasticity and plasmid dynamics across multiple species and lineages.

The paper uses genomic analysis to assess MDRO transmission within and across hospitals, finding high transmission rates for vanA VRE and linking genomic data with epidemiologic data to evaluate infection control.

The paper analyzes quinolone resistance in Haemophilus influenzae strains from 2012-2017, finding increasing BLNAR prevalence and specific mutations in GyrA associated with resistance to moxifloxacin.

This paper validates Fourier Transform Infrared (FT-IR) spectroscopy as a cost-effective method for K-type characterization of Klebsiella pneumoniae, achieving resolution comparable to whole-genome sequencing.

This study analyzes the genomes of Enterococcus faecium strains to understand their adaptive evolution, identifying plasmids as key indicators of host specificity through population-wide genomic analysis.

The paper uses targeted molecular dynamics simulations to explore the transport mechanism of substrates in the AcrB multidrug resistance pump and suggests ligand competition as a potential efflux inhibition strategy.

The paper identifies vitamin metabolizing genes in multidrug-resistant plasmids of superbugs and highlights their potential role in antibiotic resistance.

This study reconstructs genomes of drug-resistant bacteria from human faeces using metagenomic sequencing and self-organising maps, demonstrating the potential for culture-independent pathogen analysis.