Immune Response and Inflammation

This study identifies two NOD2 gene variants, E778K and G908R, as increasing susceptibility to nontuberculous mycobacterial infections through computational analysis of their structural and functional impacts.

This study compares the inflammatory responses of two rodent species to LPS, finding differences in cytokine profiles and metabolic pathways that suggest infection tolerance mechanisms in the deermouse.

This study uses in-silico methods to analyze how SARS-CoV-2 mRNA interacts with human intracellular TLRs, identifying specific viral proteins that may trigger immune responses.

A small increase in NOD1 expression leads to cancer-promoting changes in cell state by promoting persistent inflammation and oncogene expression.

The paper identifies convergent loss of TLR5 in four mammalian lineages and shows TLR11 is also absent, suggesting reduced ability to detect extracellular flagellin.

The paper analyzes the evolution of extracellular leucine-rich repeats in metazoan Toll-like receptor 4, showing distinct clade formation and varying selection pressures across repeats.

The paper evaluates a threose nucleic acid (TNA) oligonucleotide derived from a CpG sequence and finds it induces immune responses in B cell lines with minimal effects on proliferation.

The paper constructs a multiscale model of TLR4 signaling in ischemic injury to predict therapeutic outcomes and identify safe targets.